Table 2.

Mean ±standard deviation (in mm) of clinical and radiographic parameters of individual studies, arranged per intervention. Studies within each intervention are arranged alphabetically by first authors’ name. When studies included >1 groups with the same intervention, groups are reported separately

Intervention	No. Sites	Obs. period (years)	Residual PD	CAL gain	PD reduction	REC increase	Residual RDD	RDD reduction	RBL gain	PD change	CAL change	RDD change	RBL change
OFD
Bhutda & Deo, 2013	15	3 – 5	4.9 ± 0.5	1.6 ± 0.5	1.9 ± 0.4	0.3 ± 0.5	2.8 ± 0.8	1.3 ± 0.7		0.3 ± 0.8	0.5 ± 1.2
Flemmig et al., 1998	8		3.9 ± 1.5	0.8 ± 1.4	2.2 ± 1.6
Heijl et al., 1997	27		5.2 ± 1.5	1.7 ± 1.3	2.3 ± 1.0			0.0 ± 0.7
Sculean et al., 2004 a	10		5.5 ± 1.2	1.3 ± 1.2	2.7 ± 1.2	1.7 ± 0.5				0.6 ± 1.2	0.3 ± 1.1
Sculean, Schwarz et al., 2007	9		5.6 ± 1.1	1.4 ± 0.7	3.3 ± 1.4	2.0 ± 0.8				0.6 ± 0.7	0.3 ± 0.5
Nickles et al., 2009	10	>5	4.7 ± 1.3	3.7 ± 3.4	4.4 ± 2.8	0.7 ± 2.3				−0.8 ± 2.5	−0.1 ± 2.6
Petsos et al., 2019	10		4.4 ± 1.5	3.6 ± 2.6	4.4 ± 3.1	0.8 ± 2.1				−0.9 ± 0.6	−0.6 ± 0.4
Sculean, Kiss, et al., 2008	9		5.1 ± 1.3	1.8 ± 1.1	3.5 ± 1.4	1.7 ± 1.2				0.2 ± 1.6	0.2 ± 1.1
Stavropoulos & Karring, 2010	5		7.6 ± 2.1	−1.2 ± 2.4	0.2 ± 1.9	1.4 ± 1.8	5.9 ± 1.6	0.2 ± 0.1	−0.2 ± 0.6	1.4 ± 1.9	1 ± 2.6	0.6 ± 1.2	1.6 ± 0.8
Cortellini et al., 2017 b	11		4.5 ± 1.8	1.2 ± 2.4	3.3 ± 1.9	2.1 ± 1.4				1.1 ± 0.6	1.3 ± 1.2
Grafting
Flemmig et al., 1998, e	8	3 – 5	2.7 ± 2.0	2.0 ± 2.0	2.6 ± 2.2
Menezes & Rao, 2012_I	60		3.7 ± 1.0	3.1 ± 1.1	4.0 ± 0.5	1.0 ± 1.0				−2.2 ± 0.8	−2.4 ± 0.9
Mengel et al., 2006	20		4.2 ± 1.8	3.3 ± 2.1	3.5 ± 1.4	0.2 ± 1.7				0.7 ± 1.5	0.6 ± 2.6
Nevins et al., 2013_I	27			3.4 ± 0.4	4.2 ± 0.3				2.7 ± 0.4	−0.1 ± 0.3	0.3 ± 0.3		−1.3 ± 0.3
Nygaard‐Østby et al., 2010	13	>5	4.6 ± 1.8	2.2 ± 2.5	2.7 ± 1.8	0.6 ± 1.8
Orsini et al., 2008	12		3.7 ± 1.1	2.4 ± 1.1	4.2 ± 1.2	1.9 ± 1.3
Grafting + BC
Menezes & Rao, 2012_II c	60	3 – 5	2.4 ± 0.9	5.4 ± 1.2	5.8 ± 0.5	0.4 ± 0.7				−3.5 ± 0.8	−4.5 ± 1.1
Nevins et al., 2013_II d a	28			4.3 ± 0.4	4.6 ± 0.3				3.4 ± 0.3	−0.1 ± 0.3	−0.5 ± 0.3		−0.5 ± 0.3
Nevins et al., 2013_III d	28			3.5 ± 0.4	4.0 ± 0.3				2.5 ± 0.3	0.1 ± 0.3	0.1 ± 0.4		−0.3 ± 0.3
GTR
Crea et al., 2008	20	3 – 5	4.0 ± 0.9	2.1 ± 1.1	3.3 ± 1.1	1.2 ± 1.2	2.2 ± 0.6	2.7 ± 1.2		0.4 ± 0.8	0.6 ± 1.6	0.2 ± 0.7
Eickholz et al., 2004_I a	13		3.4 ± 1.1	2.4 ± 1.0	4.0 ± 1.4	1.6 ± 1.7			1.0 ± 1.6	1.0 ± 1.2	1.6 ± 1.1		−0.1 ± 3.0
Eickholz et al., 2004_II a	13		3.7 ± 1.5	2.2 ± 1.8	3.6 ± 1.6	1.4 ± 1.7			1.6 ± 2.2	0.5 ± 1.7	1.2 ± 1.9		−0.4 ± 3.0
Kim et al., 2002_I a	8		5.3 ± 1.9	1.6 ± 1.5	2.6 ± 2.0	1.0 ± 2.0
Kim et al., 2002_II a	8		4.2 ± 1.1	3.0 ± 0.7	3.6 ± 1.8	0.6 ± 1.8
Mengel et al., 2006	22		4.1 ± 1.6	3.0 ± 2.0	3.6 ± 2.0	0.6 ± 1.4				0.6 ± 1.6	0.6 ± 2.0
Sculean et al., 2001 a	12		4.7 ± 1.2	2.9 ± 2.1	3.4 ± 1.6	0.5 ± 1.4				1.1 ± 1.1	0.3 ± 1.8
Sculean et al., 2004 a	11		3.9 ± 1.4	2.7 ± 0.9	4.4 ± 1.4	1.2 ± 1.0				0.5 ± 1.5	0.5 ± 0.9
Nickles et al., 2009	10	>5	4.5 ± 1.4	2.9 ± 2.2	4.2 ± 2.5	1.3 ± 1.8				−0.2 ± 2.0	0.4 ± 1.2
Petsos et al., 2019	10		4.9 ± 1.8	3.8 ± 2.7	4.8 ± 3.4	1.0 ± 2.1				0.5 ± 0.4	0.30 ± 0.2
Pretzl et al., 2008_I a	8		5.2 ± 1.9	1.5 ± 1.2	2.4 ± 1.6	0.7 ± 1.8				−2.3 ± 1.6	1.7 ± 1.3
Pretzl et al., 2008_II a	8		3.6 ± 1.0	3.5 ± 2.5	4.2 ± 2.5	0.7 ± 1.7				−0.2 ± 1.8	−0.2 ± 2.0
Pretzl et al., 2009_I a	9		4.6 ± 2.5	2.4 ± 1.7	3.2 ± 1.3	0.7 ± 2.3	3.5 ± 1.6	2.2 ± 2.0	1.7 ± 1.5	2.0 ± 2.6	1.6 ± 2.5	−0.1 ± 1.8	−0.2 ± 1.6
Pretzl et al., 2009_II a	9		4.3 ± 1.9	2.4 ± 1.8	3.2 ± 2.3	0.7 ± 1.8	3.7 ± 3.0	1.7 ± 2.8	1.2 ± 2.5	1.2 ± 2.1	1.4 ± 1.5	0.0 ± 2.5	0.5 ± 2.6
Sculean et al., 2006	10		4.5 ± 0.8	2.9 ± 1.3	3.7 ± 0.9	0.8 ± 1.5				0.9 ± 0.7	0.1 ± 1.1
Sculean, Kiss, et al., 2008	10		5.0 ± 1.0	2.8 ± 1.2	3.4 ± 1.5	0.6 ± 1.4				0.8 ± 1.2	0.4 ± 1.2
Stavropoulos & Karring, 2010	12		5.8 ± 1.9	2.4 ± 2.1	3.0 ± 1.8	0.6 ± 2.0	1.7 ± 1.8	4.2 ± 2.0	3.6 ± 2.4	1.0 ± 1.7	0.6 ± 2.1	−0.7 ± 2.1	−0.4 ± 2.3
Cortellini et al., 2017_Ia b	13		2.9 ± 0.9	5.2 ± 2.6	5.2 ± 2.6	0.1 ± 1.2				0.9 ± 0.9	0.1 ± 1.0
Cortellini et al., 2017_II b	12		3.6 ± 1.0	3.6 ± 2.3	4.6 ± 2.3	1 ± 1.0				1.0 ± 0.8	0.5 ± 0.5
GTR + BC
Cetinkaya et al., 2014 c	11		4.7 ± 0.8	2.4 ± 0.9	2.9 ± 0.9	0.5 ± 1.2			3.5 ± 2.1
EMD
Bhutda & Deo, 2013	15	3 – 5	3.4 ± 0.6	3.2 ± 0.9	3.8 ± 1.1	0.7 ± 0.0	1.6 ± 0.7	3.2 ± 0.6		0.3 ± 0.8	0.8 ± 1.1
Crea et al., 2008	19		3.5 ± 0.8	2.5 ± 1.2	3.2 ± 1.3	0.6 ± 1.2	2.0 ± 0.7	2.7 ± 1.0		0.3 ± 0.8	0.4 ± 0.8	−0.4 ± 0.8
Heijl et al., 1997	27		4.6 ± 1.0	2.2 ± 1.1	3.1 ± 1.0			2.6 ± 1.7
Hoffmann et al., 2015	15		3.3 ± 1.9	3.8 ± 2.2	3.9 ± 2.3	0.1 ± 2.9				−0.4 ± 1.8	−1.8 ± 2.7
Ogihara & Tarnow, 2014	23		3.6 ± 0.5	3.0 ± 1.3	3.1 ± 0.7	−0.1 ± 0.8			3.3 ± 1.3	0.2 ± 0.5	0.0 ± 0.9		0.0 ± 0.8
Pietruska et al., 2012	12		4.4 ± 0.8	3.2 ± 1.3	4.4 ± 0.9	1.2 ± 0.9				0.3 ± 0.7	0.3 ± 1.1
Sculean et al., 2001 a	12		4.7 ± 1.2	3.0 ± 1.9	3.4 ± 1.6	0.4 ± 1.0				0.9 ± 1.2	0.4 ± 1.7
Sculean et al., 2004 a	11		3.9 ± 1.5	2.9 ± 1.6	4.3 ± 1.7	1.3 ± 0.7				0.3 ± 1.5	0.5 ± 1.4
Sculean, Pietruska, et al., 2007	13		4.4 ± 0.6	3.4 ± 1.4	4.2 ± 0.8	0.9 ± 1.1				0.5 ± 0.6	0.3 ± 1.0
Sculean et al., 2006	10		4.7 ± 1.2	2.8 ± 1.4	3.4 ± 1.0	0.6 ± 1.0				0.7 ± 1.1	0.4 ± 1.5
Sculean, Kiss, et al., 2008	10		4.8 ± 1.1	2.9 ± 1.4	3.6 ± 1.7	0.7 ± 1.2				0.5 ± 1.2	0.5 ± 1.4
GTR + Grafting
Cetinkaya et al., 2014	11	3 – 5	4.1 ± 0.6	2.6 ± 1.1	3.5 ± 0.9	0.8 ± 0.8			3.0 ± 2.2
Gorski et al., 2020_I	14		3.6 ± 1.3	4.8 ± 1.7	3.9 ± 1.2	0.7 ± 0.7	0.6 ± 0.5	5.1 ± 1.3	5.1 ± 1.3	0.3 ± 1.3	−0.07 ± 1.3	0.06 ± 0.3	0.01 ± 0.3
Gorski et al., 2020_II	13		3.8 ± .1.0	4.0 ± 1.7	3.3 ± 1.7	0.6 ± 0.9	0.7 ± 0.4	4.3 ± .1.6	4.4 ± 1.6	0.1 ± 1.6	0.6 ± 0.9	0.1 ± 0.4	−0.07 ± 0.5
Sculean, Schwarz, et al., 2007	10		4.3 ± 0.8	3.7 ± 1.1	4.8 ± 1.6	1.1 ± 1.2				0.6 ± 0.7	0.3 ± 0.6
Nygaard‐Østby et al., 2010	13	>5	3.4 ± 1.1	3.8 ± 1.8	4.2 ± 1.8	0.7 ± 1.1
Orsini et al., 2008	12		4.4 ± 1.1	2.5 ± 1.2	3.3 ± 1.6	0.7 ± 1.2
Stavropoulos & Karring, 2010_III a	8		4.9 ± 1.3	2.3 ± 2.1	3.6 ± 1.2	1.3 ± 1.6	1.2 ± 2.2	3.8 ± 2.1	3.7 ± 2.4	0.3 ± 1.2	0.2 ± 2.3	−1.4 ± 1.8	−0.9 ± 2.1
Stavropoulos & Karring, 2010_IV ¢	7		4.6 ± 1.2	4.1 ± 1.6	4.7 ± 1.2	0.6 ± 1.4	1.7 ± 2.4	3.9 ± 2.5	4.4 ± 2.4	0.4 ± 1.1	0.0 ± 1.7	−0.4 ± 2.4	−0.2 ± 2.3
EMD + Grafting
Döri, Arweiler, Húszár, et al., 2013_I	12	3 – 5	3.8 ± 1.3	4.3 ± 1.6	5.0 ± 1.8	0.7 ± 1.3				0.5 ± 1.2	−0.3 ± 1.4
Hoffmann et al., 2015	15		3.3 ± 1.3	4.1 ± 3.6	3.9 ± 2.0	−0.2 ± 2.3				−0.5 ± 1.7	−2.0 ± 2.8
Ogihara & Tarnow, 2014_II e	21		2.1 ± 0.4	4.2 ± 1.1	4.4 ± 0.9	0.3 ± 0.8			4.2 ± 2.4	−0.1 ± 0.4	0.0 ± 0.7		0.0 ± 0.9
Ogihara & Tarnow, 2014_III a , e	23		2.7 ± 0.5	3.6 ± 1.2	3.7 ± 0.7	0.1 ± 0.8			4.3 ± 2.3	0.0 ± 0.5	−0.1 ± 0.6		0.0 ± 0.9
Pietruska et al., 2012	12		4.7 ± 0.8	3.2 ± 1.7	4.1 ± 1.3	0.9 ± 1.1				0.4 ± 0.9	0.2 ± 1.7
Sculean, Pietruska, et al., 2007	12		4.5 ± 1.0	3.4 ± 1.4	4.1 ± 1.0	0.7 ± 0.9				0.4 ± 1.0	0.2 ± 1.1
Döri, Arweiler, Szántó, et al., 2013_I a	11	>5	4.1 ± 0.9	3.1 ± 1.3	3.9 ± 1.1	0.8 ± 0.8				0.6 ± 0.9	0.5 ± 1.0
Döri, Arweiler, Szántó, et al., 2013_II a	11		4.1 ± 0.9	3.0 ± 1.5	4.0 ± 1.2	1.0 ± 0.7				0.8 ± 0.8	0.7 ± 1.3
EMD + GTR
Sculean et al., 2004 a	10	3–5	4.4 ± 1.0	4.0 ± 1.0	2.6 ± 0.7	1.5 ± 0.7				0.4 ± 0.9	0.4 ± 0.9
Sculean, Kiss, et al., 2008	9	>5	5.1 ± 1.2	3.5 ± 1.4	2.9 ± 1.2	0.6 ± 1.1				1.0 ± 1.3	0.4 ± 1.2
EMD + Grafting + BC
Döri, Arweiler, Húszár, et al., 2013_II c	12	3 – 5	3.8 ± 1.1	4.3 ± 1.6	4.9 ± 1.5	0.6 ± 1.4				0.6 ± 1.1	−0.4 ± 1.5

Changes regard comparisons with 1 year data.

Abbreviations: BC, blood‐derived growth factor constructs; CAL, clinical attachment level; CI, confidence interval; EMD, enamel matrix derivatives; GTR, guided tissue regeneration; Obs., observation; OFD, open flap debridement; PD, probing pocket depth; RBL, radiographic bone level; RDD, radiographic defect depth; REC, gingival recession.

^aStudies/groups not contributing with data in the network meta‐analyses.

^bData recalculated to exclude patients that were re‐operated during the observation time.

^cBlood construct as adjunct;

^dRecombinant growth factor as adjunct;

^eLocal antibiotic as adjunct.