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. 2021 Mar 22;12:202. doi: 10.1186/s13287-021-02237-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Allogeneic transplantation of bioroot composites in a Sprague-Dawley rat bone defect model for 8 weeks. A (a) GFP-labelled rDFCs. A (b) Construction of cell sheets. A (c) Histological section of the TDM scaffold combined with intrinsic fibre three-dimensional dental pulp extracellular matrix, as determined by haematoxylin and eosin (HE) staining. Images of PI staining to detect the survival of grafted cells on B day 1 postimplantation and C day 3 postimplantation. TDM, treated dentin matrix; DPEM, dental pulp extracellular matrix