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Two models for TU formation. Formally, both models would result in formation of a TU. Top: recA-dependent simple homologous recombination from a IS26-based pseudo-compound transposon leading to excision and transposase-dependent replicative transposition leads to a cointegrate. Bottom: Intramolecular transposition in cis from a donor with a single IS26 leads to excision and transposase-dependent replicative transposition leads to a cointegrate
