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. 2021 Mar 23;18:80. doi: 10.1186/s12974-021-02071-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effects of ligature-induced periodontitis on inflammatory cytokines in PBMCs. Periodontal ligature induced high expression of IL-1β, IL-8, IL-6, and IL-21 in PBMCs, while these changes were alleviated by CTS. RT-PCR was performed to detect the mRNA expression of cytokines in each group: a IL-1β (n = 4, F = 4.963, p = 0.0182), b IL-6 (n = 4, F = 7.600, p = 0.0041), c IL-8 (n = 4, F = 3.889, p = 0.0374), and d IL-21 (n = 4, F = 7.568, p = 0.0042). ELISA was performed to detect the protein expression of these cytokines in plasma in each group: e IL-1β (n = 5, F = 6.460, p = 0.0045), f IL-6 (n = 5, F = 11.09, p = 0.0003), g IL-8 (n = 5, F = 7.202, p = 0.0028), and h IL-21 (n = 5, F = 12.18, p = 0.0002). (n = 4–5 per group, one-way ANOVA, *p < 0.05, **p < 0.01, and ***p < 0.001 compared to the control group; #p < 0.05, ##p < 0.01, and ###p < 0.001 compared to the CP group)