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. 2021 Mar 23;12:25. doi: 10.1186/s13229-021-00432-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Neonatal ultrasonic vocalization emissions, developmental growth, neurological reflexes and developmental delays in Arid1b^+/−. a Across neonatal developmental life, Arid1b^+/− pups displayed abnormal ultrasonic vocalization (USVs) emissions including delay of peak number of calls and decreased total number of USVs on several days compared to Arid1b^+/+. b When summed, Arid1b^+/− pups emitted significantly fewer USVs compared to Arid1b^+/+ littermate controls. c No genotype difference in axillary abdominal temperature was found, confirming fewer USVs were not the result of neonatal hypothermia. d Arid1b^+/− weighed less across development beginning at postnatal 8 and continuously throughout development compared to sex-matched Arid1b^+/+. e Across neonatal developmental life, Arid1b^+/− pups were shorter by body length (f) and narrower by head width measurements. g While Arid1b^+/− showed normal latencies to perform the righting reflex, a measure of limb coordination in early life, h Arid1b^+/− had prominent deficits in negative geotaxis (i.e., incline reorientation) and i the ability to traverse out of circle by walking. For a–c, Arid1b^+/+ N = 40, Arid1b^+/− N = 19, for d–i Arid1b^+/+ N = 29, Arid1b^+/+ N = 18. * p < .05 versus Arid1b^+/+ by repeated measures two-way ANOVA or student’s unpaired t test. Error bars represent mean ± SEM