Table 2.

Smoking-related disease GWAS SNPs associated with methylation and gene expression

SNPs	Trait	SNP-associated CpG sites	Beta of SNP-CpG association	SNP-associated expression of genes	Beta of SNP–gene expression association	Beta of CpG–gene expression association
rs8034191	Lung cancer	cg19696491	0.011	CHRNA5	0.052	0.71
rs17486278 (rs11858836 rs8034191)	Chronic obstructive pulmonary disease	cg22563815	0.013		0.05	0.88
rs57221529	Lung disease severity in cystic fibrosis	cg26850624	0.030	AHRR	0.26	1.81
rs1056562	Lung adenocarcinoma	cg03234777	0.0097	AMICA1	0.15	1.51