Table 4.

Mendelian randomization results of lung cancer using gene expression data as the exposure

Outcome	Exposure	Method	Beta	se	P value	Tissue origin
Lung cancer	CHRNA5	Inverse variance weighted	− 1.50	0.23	6.80E − 11	FHS Whole blood
Squamous cell lung cancer	CHRNA5	Inverse variance weighted	− 1.23	0.31	9.05E − 05	FHS Whole blood
Lung adenocarcinoma	CHRNA5	Inverse variance weighted	− 1.58	0.42	1.48E − 04	FHS Whole blood
Lung cancer	CHRNA5	Wald ratio	− 0.22	0.03	9.24E − 13	GTEx lung
Lung adenocarcinoma	CHRNA5	Wald ratio	− 0.23	0.05	5.13E − 07	GTEx lung
Squamous cell lung cancer	CHRNA5	Wald ratio	− 0.17	0.05	3.86E − 04	GTEx lung