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Bidirectional Mendelian randomization results of DNA methylation of CHRNA5 and smoking
| Exposure | Outcome | Instrumental variant | Method | beta | se | P value |
|---|---|---|---|---|---|---|
| cg19696491 | Pack-years of smoking | rs12915652 | Wald ratio | − 1.50 | 0.21 | 4.94E − 13 |
| cg22563815 | Pack-years of smoking | rs12915652 | Wald ratio | − 1.32 | 0.18 | 4.94E − 13 |
| Pack-years of smoking | cg22563815 | 9 SNPs | Inverse variance weighted | − 0.077 | 0.031 | 0.012 |
| Pack-years of smoking | cg19696491 | 9 SNPs | Inverse variance weighted | − 0.067 | 0.026 | 0.01 |
