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. 2021 Mar 23;9:49. doi: 10.1186/s40478-021-01152-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — MAPT (Tau mRNA transcript) expression in astrocytes from human adult brain. Shown are results from three different single-cell and single-nucleus RNAseq studies (from outside laboratories) which analyzed mRNA transcripts in human brain samples. Pie charts (a, c, e, g) show that the proportion of astrocytes that express MAPT was remarkably similar (~ 1/4th of astrocytes evaluated express MAPT transcript) in all three studies. Among the astrocytes that expressed any MAPT (b, d, f), the amount of MAPT transcripts detected in astrocytes was approximately the same as in neurons in the same brains. In AD astrocytes that express MAPT (f), the level of MAPT transcripts detected was higher than in MAPT expressing control astrocytes