Figure 1.
Schematic representation of an immunoglobulin G1 (IgG1) half molecule. Domains are labeled in bold and cysteines are shown in italic. The antigen‐binding fragment (Fab) consists of the variable (VL) and constant (CL) domains of the light chain, and the variable (VH) and constant (CH1) domains of the heavy chain. The Fab fragment is connected via the hinge region to the crystallizable fragment (Fc), consisting of the constant domains CH2 and CH3 of the heavy chain. A total of 16 disulfide bonds stabilize the native IgG1 structure, as represented by dashed lines connecting the cysteines involved