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. 2020 Apr 15;14(3):876–883. doi: 10.1093/ckj/sfaa026

Table 2.

Demographic, serological and clinical findings in patients with MN and viral infection

Treatment
Last follow-up
Case no MN age Sex Ethnicity Virology PLA2R biopsy THSD7A Lupus serology Viral load CD4 cells/uL GFR uPCR anti-PLA2R serum MN Anti-viral FU months GFR uPCR anti-PLA2R serum Complications
1 23 F Asian HBV Neg No tissue Neg HBV 83 210 copies/mL NA >60 590 NA Tacrolimus Tenofovir 24 >60 0 NA Nephrotic in pregnancy
2 43 F Asian HBV Pos NA Neg HBV 1190 iu/mL NA >90 1030 75 Tacrolimus Entecavir 48 48 229 2 Crescentic transformation, treated with RTX and CyP
3 39 M Asian HBV Pos NA Neg HBV <100 copies/mL NA 55 170 NA Tacrolimus Lamivudine 48 50 0 NA None
4 65 F Caucasian HBV Pos NA Neg HBV <20 copies/mL NA 89 1337 99 Supportive None 7 81 542 28 None
5 39 F Asian HBV Neg Pos Neg HBV<20 copies/mL NA >90 675 Neg Supportive None 32 >90 240 NA None
6 26 M Asian HBV Pos NA Neg HBV <20 copies/mL NA >90 896 30 Tacrolimus Tenofovir 15 >90 57 9 None
7 50 M Caucasian HCV Pos NA Neg HCV undetectable NA >60 1253 NA Tacrolimus Interferon and ribavirin 132 HD HD 3 Relapse, treated with CyP and steroids, ESRD
8 68 M Asian HCV Pos NA Neg HCV undetectable NA >90 801 93 Tacrolimus Interferon 46 80 425 2 Guillain-Barre pre-MN, flare MN treated with RTX
9 41 M Caucasian HCV Pos NA ANA+ 1:160 HCV undetectable NA >90 1800 110 Tacrolimus None 39 >90 570 3.5 Alc liver disease, non- compliant, changed to RTX
10 33 F Asian HCV Neg Neg Neg HCV undetectable NA >90 1.989 Neg Tacrolimus None 15 >90 51 NA None
11 31 M Afro-Caribbean HIV Neg NA Neg HIV 1489 copies/mL 800 67 65 NA Supportive None 64 75 53 NA None
12 46 M Caucasian HIV Neg Pos Neg HIV 81 copies/mL 630 >90 854 Neg Tacrolimus Atazanavir, emtricitabine, ritonavir and tenofovir 64 47 47 NA None
13 26 M Afro-Caribbean HIV Neg Neg Neg HIV <20 copies/mL 477 >90 77 NA Supportive Abacavir, darunavir, lamividine and ritonavir 16 >90 50 NA None
14 47 F Afro-Caribbean HIV Pos NA Neg HIV <20 copies/mL 558 >90 207 NA Supportive Abacavir, lamivudine and rilpivirine 42 >90 220 NA None
15 44 F Afro-Caribbean HIV Neg Pos Neg HIV <20 copies/mL 600 16 548 NA Supportive Abacavie, darunavir, lamivudine and ritonavir 27 HD HD NA ESRD
16 37 F Afro-Caribbean HIV Pos NA Neg HIV <20 copies/mL 480 82 22 22 RTX Abacavir, efavirenz and lamivudine 6 82 22 NA Relapse at 5 years—retreated with RTX
17 25 F Afro-Caribbean HIV HBV Neg Neg Neg HBV 102 copies/mL HIV <20 copies/mL NA >60 286 NA Supportive Abacavir, entacavir, lamivudine, lopinavir and ritonavir 6 >60 150 NA None
18 74 M Afro-Caribbean HIV HBV Pos NA Neg HBV undetectable HIV 21 copies/mL 505 61 2.406 67 Tacrolimus Efavirenz, emtricitabine and tenofovir 6 61 626 34 Prostate cancer
19 73 M Caucasian HIV HCV Neg Neg Neg HCV undetectable HIV <20 copies/mL 571 44 133 Neg Supportive Emtricitabine, rilpivirine and tenofovir 10 57 52 NA None

Lupus serology: antinuclear antibody, double-stranded DNA and endonuclear antibody; GFR: mL/min/1.73 m2; UPCR: mg/mmol; anti-PLA2R antibodies: IU/mL; FU: follow-up; HD: haemodialysis; ESRD: end-stage renal disease; Pos: positive; Neg: negative; NA: not available.