Table 2.
Treatment |
Last follow-up |
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Case no | MN age | Sex | Ethnicity | Virology | PLA2R biopsy | THSD7A | Lupus serology | Viral load | CD4 cells/uL | GFR | uPCR | anti-PLA2R serum | MN | Anti-viral | FU months | GFR | uPCR | anti-PLA2R serum | Complications |
1 | 23 | F | Asian | HBV | Neg | No tissue | Neg | HBV 83 210 copies/mL | NA | >60 | 590 | NA | Tacrolimus | Tenofovir | 24 | >60 | 0 | NA | Nephrotic in pregnancy |
2 | 43 | F | Asian | HBV | Pos | NA | Neg | HBV 1190 iu/mL | NA | >90 | 1030 | 75 | Tacrolimus | Entecavir | 48 | 48 | 229 | 2 | Crescentic transformation, treated with RTX and CyP |
3 | 39 | M | Asian | HBV | Pos | NA | Neg | HBV <100 copies/mL | NA | 55 | 170 | NA | Tacrolimus | Lamivudine | 48 | 50 | 0 | NA | None |
4 | 65 | F | Caucasian | HBV | Pos | NA | Neg | HBV <20 copies/mL | NA | 89 | 1337 | 99 | Supportive | None | 7 | 81 | 542 | 28 | None |
5 | 39 | F | Asian | HBV | Neg | Pos | Neg | HBV<20 copies/mL | NA | >90 | 675 | Neg | Supportive | None | 32 | >90 | 240 | NA | None |
6 | 26 | M | Asian | HBV | Pos | NA | Neg | HBV <20 copies/mL | NA | >90 | 896 | 30 | Tacrolimus | Tenofovir | 15 | >90 | 57 | 9 | None |
7 | 50 | M | Caucasian | HCV | Pos | NA | Neg | HCV undetectable | NA | >60 | 1253 | NA | Tacrolimus | Interferon and ribavirin | 132 | HD | HD | 3 | Relapse, treated with CyP and steroids, ESRD |
8 | 68 | M | Asian | HCV | Pos | NA | Neg | HCV undetectable | NA | >90 | 801 | 93 | Tacrolimus | Interferon | 46 | 80 | 425 | 2 | Guillain-Barre pre-MN, flare MN treated with RTX |
9 | 41 | M | Caucasian | HCV | Pos | NA | ANA+ 1:160 | HCV undetectable | NA | >90 | 1800 | 110 | Tacrolimus | None | 39 | >90 | 570 | 3.5 | Alc liver disease, non- compliant, changed to RTX |
10 | 33 | F | Asian | HCV | Neg | Neg | Neg | HCV undetectable | NA | >90 | 1.989 | Neg | Tacrolimus | None | 15 | >90 | 51 | NA | None |
11 | 31 | M | Afro-Caribbean | HIV | Neg | NA | Neg | HIV 1489 copies/mL | 800 | 67 | 65 | NA | Supportive | None | 64 | 75 | 53 | NA | None |
12 | 46 | M | Caucasian | HIV | Neg | Pos | Neg | HIV 81 copies/mL | 630 | >90 | 854 | Neg | Tacrolimus | Atazanavir, emtricitabine, ritonavir and tenofovir | 64 | 47 | 47 | NA | None |
13 | 26 | M | Afro-Caribbean | HIV | Neg | Neg | Neg | HIV <20 copies/mL | 477 | >90 | 77 | NA | Supportive | Abacavir, darunavir, lamividine and ritonavir | 16 | >90 | 50 | NA | None |
14 | 47 | F | Afro-Caribbean | HIV | Pos | NA | Neg | HIV <20 copies/mL | 558 | >90 | 207 | NA | Supportive | Abacavir, lamivudine and rilpivirine | 42 | >90 | 220 | NA | None |
15 | 44 | F | Afro-Caribbean | HIV | Neg | Pos | Neg | HIV <20 copies/mL | 600 | 16 | 548 | NA | Supportive | Abacavie, darunavir, lamivudine and ritonavir | 27 | HD | HD | NA | ESRD |
16 | 37 | F | Afro-Caribbean | HIV | Pos | NA | Neg | HIV <20 copies/mL | 480 | 82 | 22 | 22 | RTX | Abacavir, efavirenz and lamivudine | 6 | 82 | 22 | NA | Relapse at 5 years—retreated with RTX |
17 | 25 | F | Afro-Caribbean | HIV HBV | Neg | Neg | Neg | HBV 102 copies/mL HIV <20 copies/mL | NA | >60 | 286 | NA | Supportive | Abacavir, entacavir, lamivudine, lopinavir and ritonavir | 6 | >60 | 150 | NA | None |
18 | 74 | M | Afro-Caribbean | HIV HBV | Pos | NA | Neg | HBV undetectable HIV 21 copies/mL | 505 | 61 | 2.406 | 67 | Tacrolimus | Efavirenz, emtricitabine and tenofovir | 6 | 61 | 626 | 34 | Prostate cancer |
19 | 73 | M | Caucasian | HIV HCV | Neg | Neg | Neg | HCV undetectable HIV <20 copies/mL | 571 | 44 | 133 | Neg | Supportive | Emtricitabine, rilpivirine and tenofovir | 10 | 57 | 52 | NA | None |
Lupus serology: antinuclear antibody, double-stranded DNA and endonuclear antibody; GFR: mL/min/1.73 m2; UPCR: mg/mmol; anti-PLA2R antibodies: IU/mL; FU: follow-up; HD: haemodialysis; ESRD: end-stage renal disease; Pos: positive; Neg: negative; NA: not available.