Table 3.
HRs for all-cause mortality of tertiles of FGF23 change during 6 months
| Tertiles | Stable FGF23 (n = 115) | Decreasing FGF23 (n = 114) | Increasing FGF23 (n = 114) |
|---|---|---|---|
| Median change of FGF23a | −275 (−825–33) | −4972 (−14 418 to −2582) | 3339 (1226–7310) |
| Ref. | HR (95% CI) | HR (95% CI) | |
| Crude | Ref. | 0.96 (0.61–1.50) | 1.56 (1.03 – 2.35*) |
| Model 1b | Ref. | 1.26 (0.79–2.01) | 2.01 (1.32 – 3.07*) |
| Model 2c | Ref. | 1.25 (0.78–2.02) | 2.01 (1.32 – 3.07*) |
| Model 3d | Ref. | 1.25 (0.78–2.02) | 2.00 (1.30 – 3.09*) |
Results are shown as HRs with 95% CIs. All models are adjusted for transplantation by adding transplantation as a time-varying covariate.
a
Depicted are median change of FGF23 concentrations (RU/mL) in 6 months with IQR.
b
Model 1 = adjusted for age, sex, diabetes, history of CVD, dialysis vintage, residual kidney function and phosphate.
c
Model 2 = Model 1 plus adjustment for baseline FGF23 concentration.
d
Model 3 = Model 2 plus adjustment for dialysis modality.
Asterisks indicate a statistically significant difference in hazard at the level of P ≤ 0.05.