Extended Data Figure 10. Tyramine’s inhibition of stress resistance requires intestinal hid-1.

Survival percentages of young adult hid-1 mutant animals expressing either the endogenous (endog. rescue), the neuronal (neu. rescue) or the intestinal (int. rescue) rescue constructs exposed to oxidation (left) or heat (4 h, 35°C) (right) in the absence or presence of 10 mM TA. Bars represent mean ± SEM from independent experiments. The number of independent experiments for each condition (n) is shown in the figure. 80–100 animals per condition per experiment were used. A Two-tailed Student’s t test (versus same strain without TA) was used. hid-1 expression in the intestine in hid-1 mutants restores the negative impact of tyramine on oxidative and heat stress resistance.