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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Trends Pharmacol Sci. 2020 Feb 26;41(4):266–280. doi: 10.1016/j.tips.2020.01.011

Figure 5: Seeking consensus on the existence and nature of higher-order interactions.

Figure 5:

A) Average Loewe synergy decreases for an increasing number of drugs in three datasets (Russ et al. [56], Katzir et al. [59], and Tekin et al. [34]). The black dot is the mean value of the distribution. Red-line demarcates synergy (Syn) from antagonism (Ant). The species tested in each paper are indicated in the panel title. B) Distribution of Bliss synergy as a function of increasing numbers of drugs. Accounting for the difference between percent effect and percent affect reduced the bias toward antagonism for ultra-high order combinations in the Katzir et al. data (Figure S6A).

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