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. 2021 Mar 23;20:75. doi: 10.1186/s12934-021-01563-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Glycine, serine, and threonine metabolism pathways of L. gasseri HHuMIN D. Solid arrows indicate that the metabolism pathways of glycine, serine, and threonine are effective and dashed arrows indicate invalid: sdaA/sdaB/tdcG L-serine dehydratase, glyA/SHMT glycine hydroxymethyltransferase, AGXT alanine-glyoxylate transaminase, glxK/garK glycerate 2-kinase, serA/PHGDH D-3-phosphoglycerate dehydrogenase, serC/PSAT1 phosphoserine aminotransferase, serB/PSPH phosphoserine phosphatase, thrH/phosphoserine homoserine phosphotransferase, CBS cystathionine beta-synthase, CHO1/pssA CDP-diacylglycerol–-serine O-phosphatidyltransferase, trpA tryptophan synthase alpha chain; and trpB, tryptophan synthase beta chain. Whole genome sequencing of L. gasseri HHuMIN D was performed by Chunlab, Inc. (Seoul, Korea), which used PacBio Sequel Systems (Pacific Biosciences, Menlo Park, CA, USA) and analyzed using CLgenomics™ and EZBioCloud Apps programs (Chunlab, Seoul, Korea). Biosynthetic pathways of glycine, serine, and threonine were analyzed by matching with the KEGG pathway using complete genome sequencing of L. gasseri HHuMIN D via CL Genomics™ (ChunLab, Seoul, South Korea, 2004). The activities of related genes and substances produced can be inferred through the biosynthetic pathways provided by KEGG