Table 1.

2 × 2 factorial design of parent trial

		Human intervention
		RACD* (reactive case detection) 28 clusters	rfMDA† (reactive focal mass drug administration) 28 clusters
Mosquito intervention
No RAVC		A	B
(no reactive focal vector control)		RACD only arm	rfMDA only arm
28 clusters		14 clusters	14 clusters
RAVC‡		C	D
(reactive focal vector control)		RACD + RAVC arm	rfMDA + RAVC arm
28 clusters		14 clusters	14 clusters

*RACD (reactive case detection): administering rapid diagnostic tests to people living within a 500 m radius of an index case; treating positives with artemether-lumefantrine and single dose primaquine

^†rfMDA (reactive focal mass drug administration): presumptively treating individuals living within a 500 m radius around an index case using artemether-lumefantrine, without testing

^‡RAVC (reactive focal vector control): spraying long-acting insecticide, pirimiphos-methyl, on interior walls of sleeping structures in a 7-household radius around an index case