Table 3.
Comparison of DADA2 patients between China and other countries
| DADA2 patients from China (n = 7) |
DADA2 patients from Other countries ref. 2(n = 161) |
P Value | |
|---|---|---|---|
| Gender M: F | 57%: 43% | 53%: 47% | – |
| Onset age < 1y | 3 (42%) | 38 (24%) | NS |
| Fever | 7 (100%) | 81 (50%) | 0.014 |
| Skin manifestations | 7 (100%) | 121 (75%) | NS |
| Livedo reticularis | 6 (86%) | 81 (50%) | NS |
| Digital necrosis | 1 (14%) | 36 (22%) | NS |
| Aphtous ulcers | 1 (14%) | 11 (7%) | NS |
| CNS ischemic stroke | 2 (29%) | 43 (27%) | NS |
| CNS hemorrhagic stroke | 1 (14%) | 19 (12%) | NS |
| Abdominal pain | 3 (43%) | 19 (12%) | 0.048 |
| Splenomegaly | 0 (0%) | 47 (29%) | NS |
| Hepatomegaly | 0 (0%) | 31 (19%) | NS |
| Nephrological manifestations | 2 (29%) | 23 (14%) | NS |
| Hypertension | 1 (14%) | 34 (21%) | NS |
| Arthritis | 2 (29%) | 23 (14%) | NS |
| Neutropenia | 0 (0%) | 11 (7%) | NS |
| Anemia | 2 (29%) | 21 (13%) | NS |
| Lymphopenia | 0 (0%) | 26 (16%) | NS |
| Hypogammaglobulinemia | 2 (29%) | 36 (22%) | NS |
| Low IgM | 3 (42%) | 29 (18%) | NS |
| Low IgA | 0 (0%) | 19 (12%) | NS |
CNS Central nervous system, NS No significance