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. 2021 Mar 22;21:100. doi: 10.1186/s12906-021-03270-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Tanshinone IIA (TIIA) + cyclosporine A (CsA) preserved myocardial architecture in renal ischemia-reperfusion (IR)-induced myocardial injury. Rats were pre-treated with TIIA alone or in combination with CsA followed by removing the right kidney and clamping of the left renal artery for 30 min and reperfusion for 24 h. Sham rats were used as control. Representative photomicrographs of myocardial histology (a), the scale bars represents a length of 200 μm on histology, myocardial injury scores (a) were evaluated under different conditions. The scale bars represents a length of 200 μm on histology. Electron microscope pictures (40000×) of rats myocardial tissue after renal ischemia-reperfusion (IR). Abnormal mitochondrial (paired yellow arrow) morphology show that mitochondrial membrane rupture or swellings, normal mitochondrial (single yellow arrow) morphology type show that mitochondrial membrane smooth and inner carinulae distinct (b), and percentage of damaged mitochondria (b). Data are shown as mean ± SD. *p < 0.05 versus sham group, ^#p < 0.05 versus IR (obese) group, ^△p < 0.05 versus TIIA group, ^▲p < 0.05 versus CsA group. Data are shown as mean ± SD. *p < 0.05 versus sham group, ^#p < 0.05 versus IR (obese) group, ^△p < 0.05 versus TIIA group, ^▲p < 0.05 versus CsA group