Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 8;8(2):ENEURO.0208-20.2020. doi: 10.1523/ENEURO.0208-20.2020

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Dzhala and Staley

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Figure 2. — Effects of the KCC2 blocker VU0463271 on recurrent IEDs at DIV5–DIV7. A, C, Extracellular field potential recordings in the CA1 pyramidal cell layer in the organotypic hippocampal slices at DIV6 before (control), during and after application of 0.1 μm (A) and 1 μm (C) VU0463271 for 10 min. Expansion of IEDs in control and in the presence of VU0463271. B, D, Corresponding summary plots of the frequency and mean duration of recurrent IEDs in individual cultures (open symbols) and corresponding power of electrical activity in 5-min windows. Filled symbols indicate group mean ± SD. VU0463271 (1 μm) significantly increased the mean frequency, duration, and power of epileptiform discharges (n/s corresponds to p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001, one-way RM ANOVA, Tukey’s test).