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. Author manuscript; available in PMC: 2021 Mar 23.
Published in final edited form as: J Leukoc Biol. 2020 May 9;107(6):883–892. doi: 10.1002/JLB.4HI0420-098R

Figure 3. Patrolling monocytes increase their expression of LFA-1 on their surface in the lung environment and require integrins for sensing tumor cells.

Figure 3.

A) MFI of beta integrins ß1 and ß2) present on Ly6C- monocytes from blood and lung in healthy WT mice by flow cytometry. n = 4 mice per group. B) Frequency of CD115+ monocytes in the lungs of E2:integrin KO BMT and C) the specific frequency of Ly6C− monocytes in the lungs of E2:integrin KO BMT mice. n = 4 mice per group. Numbers of Ly6C− D) or Ly6C+ E) monocytes that are positive for B16F10 cell particles (CellTrace Violet-labeled) 16 hours after i.v. injection in E2:integrin KO BMT mice, n = 4 mice per group. Multiple t tests with Holm-Sidak method for grouped analysis, Kruskal-Wallis nonparametric test for multiple comparisons. ns = not significant, *p<0.05.