TABLE 1.
Characteristics of studies
| Study | Year | Region | Design | Total number | HBsAg seroclearance number | HBsAg seroreversions number | Male (%) | Age (mean or median) | Follow‐up years after HBsAg seroclearance (mean or median) | Liver cirrhosis | HCC incidences | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Post‐NUC/IFN | Total | HBsAg(+) | DNA(+) | ||||||||||
| Wu | 2019 | China | Retrospective | 1276 | 238 | 238 | 16 | 8 | 2 | 63.9 | 36 ± 11 | 3.08 (1.3–4.7) | 0 | 0/238 |
| Suárez | 2019 | Spain | Retrospective | 69 | 69 | 69 | 1/64 | 0 | 1 | 91.3 | 51.7 ± 11.9 | 3.15 (2.0–4.6) | 10 | 1/69 |
| Alawad | 2019 | USA | Retrospective | 787 | 65 | 46 | 3 | 2 | 0 | 80 | 49 ± 14 | 9.58 (1.1–29.4) | 7 | 0/65 |
| Li | 2019 | China | Prospective | 172 | 172 | 172 | 23 | 19 | 1 | 78.41 | 42.60 ± 10 | 1 | 14 | 1/172 |
| Yip | 2018 | Hongkong, China | Retrospective | 4080 | 2211 | 365 | 89 | 89 | 0 | 63.1 | 56.8 ± 14 | 1.95 (0.8–3.5) | NA | 24/2122 |
| Stelma | 2017 | The Netherlands | Prospective | 92 | 16 | 16 | 0 | 0 | 0 | 73.9 a | 39.5 (19–69) a | 5 | 14 a | 1/92 a |
| Chi | 2017 | The Netherlands, Canada, China | Retrospective | 5872 | 54 | 54 | 6 | 1 | 5 | 87 | 48 ± 12 | 1.6 (0.5–2.7) | 8 | 0/54 |
| Wong | 2017 | Asian | Retrospective | 1072 | 49 | 49 | 6 | 6 | 0 | 64.6 a | NA | 2.27 | 88 a | 44/1072 a |
| Seto | 2016 | Hongkong, China | Retrospective | 51 | 51 | 51 | 2 | 1 | 0 | 82.4 | 48.7 (39.3–58.6) | 4.3 (2.0–6.9) | 5 | NA |
| Li | 2016 | China | Retrospective | 28 | 28 | 28 | 0 | 0 | 0 | 92.9 | 47.1 (27–67) | 2.3 (0.8–7.5) | NA | NA |
| Lauret | 2015 | Spain | Prospective | 612 | 78 | 22 | 2 | 2 | 0 | 71.79 | 49.5 (16–74) | 5.13 (0.7–17.1) | 12 | 1/78 |
| Kim, Lim | 2014 | Korea | Retrospective | 5409 | 110 | 110 | 7 | 1 | 6 | 76.36 | 42 ± 10 | 2.1 (287 patient‐years) | 34 | 1/110 |
| Chu | 2012 | Taiwan, China | Retrospective | 118 | 118 | 0 | 21 | 0 | 21 | 85 | 51.1 ± 9.4 | 10 | 10 | NA |
| Yuen | 2008 | Hongkong, China | Retrospective | 298 | 298 | 13 | 6/99 | 0 | 6 | 70.81 | 49.6 (4.1–84.7) | 3.03 (0.5–18.5) | NA | 7/298 |
| Arase | 2006 | Japan | Retrospective | 231 | 231 | 75 | 4 | 0 | 4 | 80.52 | 51 (23–66) | 6.5 (1–23.6) | 67 | 2/231 |
| Yip | 2019 | Hongkong, China | Retrospective | 17,499 | 376 | 376 | NA | NA | NA | 74.2 | 47.8 ± 14.2 | 5.9 (3.8–7.7) | 23 | 2/376 |
| Song | 2018 | China | Prospective | 3635 | 652 | 0 | NA | NA | NA | NA | NA | 9 a | NA | 8/652 |
| Yip | 2017 | Hongkong, China | Retrospective | 4568 | 4568 | 853 | NA | NA | NA | 62.9 | 56.7 ± 13.8 | 3.4 (1.5–5.0) | 839 | 54/4568 |
| Chen | 2016 | Taiwan, China | Retrospective | 422 | 422 | 110 | NA | NA | NA | 76.3 | 50.4 ± 11.2 | 8.93 ± 5.62 | 44 | 5/422 |
| Gounder | 2016 | Alaska | Retrospective | 1346 | 238 | 0 | NA | NA | NA | 64 | 28.8 (15.9–42.2) | 11.7 (6.5–18.3) | NA | 3/226 |
| Park | 2016 | Korea | Retrospective | 1919 | 90 | 0 | NA | NA | NA | 65.56 | NA | NA | 24 | 4/83 |
| Tseng | 2015 | Taiwan, China | Retrospective | 2121 | 338 | 0 | NA | NA | NA | 71.6 | 28‐75 a | 3 a | 0 | 5/338 |
| Ferreira | 2014 | Brazil | Retrospective | 548 | 40 | 0 | NA | NA | NA | 55 | 37.7 ± 13.3 | 15.8 a | 0 | 0/40 |
| Cho | 2014 | Korea | Retrospective | 2392 | 166 | 17 | NA | NA | NA | 63.3 a | 49.3 ± 0.6 a | 3.53 | NA | 10/166 |
| Kim, Lee | 2014 | Korea | Retrospective | 829 | 829 | 105 | NA | NA | NA | 69.36 | 52.3 ± 9.3 | 3.2 (1.8–6.1) | 98 | 19/829 |
| Orito | 2014 | Japan | Retrospective | 602 | 13 | 13 | NA | NA | NA | 63.3 a | 52 (21–79) a | 7.5 a | 0 | 0/13 |
| Liu | 2014 | Taiwan, China | Prospective | 2946 | 529 | 0 | NA | NA | NA | 75.43 | 30–60 | 48,149.1 p/y a | 0 | 8/529 |
| Tseng | 2012 | Taiwan, China | Prospective | 668 | 130 | NA | NA | NA | NA | 54.5 a | ≥28 | 9.4 ± 5.7 | 1 | 1/130 |
| Idilman | 2012 | Turkey | Retrospective | 183 | 10 | 10 | NA | NA | NA | 66.6 | 45.5 ± 11 | 2.87 ± 1.87 | 0 | 0/10 |
| Kim Ji Hoon | 2011 | Korea | Retrospective | 96 | 96 | 5 | NA | NA | NA | 80.21 | 46.4 ± 9.9 | 4.7 (0.6–19.8) | 24 | 6/96 |
| Fwu | 2009 | Taiwan, China | Retrospective | 1,782,401 | 31,088 | NA | NA | NA | NA | 0 | 28.72 ± 4.23 a | 8.07 a | 0 | 8/31,088 |
| Moucari | 2009 | France | Retrospective | 97 | 28 | 28 | NA | NA | NA | 82.14 | 43 (23–73) a | 14 a | 10 | 0/28 |
| Kim Jeong | 2008 | Korea | Retrospective | 215 | 11 | 0 | NA | NA | NA | 54.55 | 52 (40–67) | 2.5 | 0 | 0/11 |
| Nam | 2007 | Korea | Retrospective | 4061 | 47 | 0 | NA | NA | NA | 64.98 a | 46.2 ± 15.7 | 7.3 a | 7 | 9/47 |
| Ahn | 2005 | Korea | Retrospective | 49 | 49 | 0 | NA | NA | NA | 73.47 | 50 (27–72) | 1.6 (0.4–3.2) | 17 | 5/49 |
| Yuen | 2004 | Hongkong, China | Retrospective | 184 | 92 | 6 | NA | NA | NA | 70.65 | 48.8 ± 13.81 | 4.3 | NA | 5/92 |
| Chen | 2002 | Taiwan, China | Retrospective | 218 | 218 | 0 | NA | NA | NA | 78.9 | 44.8 ± 11.1 | 5.1 (1–14.9) | 29 | 3/218 |
| McMahon | 2001 | USA | Retrospective | 1536 | 106 | NA | NA | NA | NA | 59.1 | NA | 12.3 a | NA | 2/106 |
Abbreviation: NA, Not available.
a
Data from the whole cohort.