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. 2021 Jan 29;599(6):1855–1883. doi: 10.1113/JP281044

Figure 11. The Na+/K+ ATPase pump blocker ouabain does not block I Nab .

Figure 11

A, recording of the electrical activity of mouse CCs current‐clamped at RMP. The cells were sequentially challenged by a bath‐application of ouabain (300 μM), followed by a low Na+ (NMDG substitution) + ouabain‐containing saline. Ouabain per se induced a membrane hyperpolarization, both in spontaneously firing (Aa) and silent (Ab) cells. B, pooled data illustrating the membrane potential changes in response to low Na+ in the presence of ouabain. A further application of low Na+ saline in presence of ouabain increased hyperpolarization in both cells.