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. 2021 Jan 15;60(6):3008–3015. doi: 10.1002/anie.202011593

Scheme 3.

Scheme 3

Synthesis of the Lx conjugates trastuzumab‐Lx‐AF (3 a and 3 b) from the chlorido semi‐final complex Cl‐Lx‐AF (1 f), comparing the initial and the optimized Lx conjugation methods.