TABLE 2.
The association between MBL polymorphisms and RA risk in meta‐analysis
| Sub‐group analysis | No. of data sets | No. of cases/controls | Allele model (T vs C) | Dominant model (CC vs TT + CT) | Recessive model (TT vs CC + CT) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR (95% CI) | P OR | P H | OR (95% CI) | P OR | P H | OR (95% CI) | P OR | P H | ||
| Brazilian | ||||||||||||
| rs1800450 | 2 | 754 | 740 | 1.32 (1.04‐1.67)∗ | <.05 | .546 | 1.30 (1.04‐1.62)∗ | <.05 | .225 | 1.55 (0.59‐4.12) | .377 | .141 |
| rs7096206 | 2 | 736 | 752 | 1.06 (0.83‐1.35) | .666 | .058 | 1.00 (0.78‐1.27) | .969 | .146 | 1.54 (0.74‐3.20) | .248 | .070 |
| MBL‐A/O | 5 | 2432 | 2479 | 1.20 (1.08‐1.34)** | <.001 | .959 | 1.18 (1.07‐1.31)∗ | <.05 | .890 | 1.39 (0.95‐2.05) | .093 | .379 |
| Overall | 9 | 3922 | 3971 | 1.20 (1.09‐1.31)*** | <.0001 | .597 | 1.17 (1.07‐1.27) *** | <.0001 | .489 | 1.44 (1.04‐1.99)∗ | <.05 | .298 |
| Caucasian | ||||||||||||
| rs1800450 | 1 | 409 | 260 | 0.88 (0.58‐1.34) | .556 | NA | 0.84 (0.55‐1.26) | .391 | NA | 1.57 (0.31‐7.94) | .588 | NA |
| MBL‐A/O | 3 | 1510 | 2092 | 1.06 (0.94‐1.20) | .357 | .170 | 1.04 (0.94‐1.16) | .463 | .176 | 1.20 (0.81‐1.78) | .372 | .310 |
| MBL‐YA/O | 1 | 829 | 1003 | 0.93 (0.80‐1.08) | .326 | NA | 0.91 (0.80‐1.03) | .141 | NA | 1.07 (0.66‐1.75) | .779 | NA |
| Overall | 5 | 2748 | 3355 | 1.00 (0.91‐1.10) | .973 | .225 | 0.98 (0.90‐1.06) | .592 | .180 | 1.16 (0.86‐1.57) | .335 | .623 |
| East Asian | ||||||||||||
| rs5030737 | 1 | 562 | 772 | 0.17 (0.04‐0.73) * | <.05 | NA | 0.18 (0.04‐0.78) * | <.05 | NA | NA | ||
| rs1800450 | 5 | 1735 | 2017 | 1.02 (0.88‐1.19) | .769 | .012 | 0.99 (0.85‐1.14) | .872 | .011 | 1.44 (0.81‐2.56) | .214 | .426 |
| rs7096206 | 3 | 1320 | 1492 | 1.06 (0.90‐1.24) | .495 | .062 | 1.04 (0.90‐1.21) | .567 | .082 | 1.28 (0.63‐2.61) | .499 | .647 |
| rs11003125 | 3 | 1649 | 1800 | 1.16 (1.06‐1.26) * | <.05 | .692 | 1.05 (0.98‐1.13) | .133 | .338 | 1.56 (1.25‐1.94) | <.0001 | .783 |
| Overall | 12 | 5266 | 6081 | 1.09 (1.02‐1.17)* | <.05 | .003 | 1.02 (0.96‐1.09) | .531 | .005 | 1.52 (1.24‐1.84) | <.0001 | .851 |
| Indian | ||||||||||||
| rs5030737 | 2 | 520 | 556 | 1.56 (0.98‐2.48) | .062 | .475 | 1.56 (1.00‐2.44) | .053 | .459 | NA | NA | NA |
| rs1800450 | 2 | 508 | 628 | 0.31 (0.21‐0.46)*** | <.0001 | .850 | 0.31 (0.21‐0.46)*** | <.0001 | .766 | 0.24 (0.01‐4.98) | .357 | NA |
| rs1800451 | 2 | 500 | 552 | 0.93 (0.52‐1.67) | .802 | .416 | 0.93 (0.52‐1.64) | .798 | .406 | NA | NA | NA |
| rs7096206 | 2 | 620 | 529 | 1.09 (0.88‐1.34) | .434 | .168 | 1.12 (0.92‐1.36) | .268 | .392 | 0.94 (0.52‐1.71) | .836 | .130 |
| rs11003125 | 2 | 792 | 714 | 1.03 (0.94‐1.14) | .524 | .766 | 1.03 (0.96‐1.11) | .415 | .579 | 1.03 (0.83‐1.28) | .760 | .985 |
| Overall | 10 | 2940 | 2979 | 1.07 (0.98‐1.18)*** | .184 | <.0001 | 1.09 (1.00‐1.19) | .085 | <.0001 | 1.00 (0.82‐1.23) | .981 | .510 |
Abbreviations: C, represent wild‐type allele; 95%CI, 95% confidence interval; OR, odd ratio; P OR, P value for the test of association; P H, P value for heterogeneity analysis; T, represent minor allele; NA, none.
∗
P OR < .05.
**
P OR < .001.
***
P OR < .0001.