. 2021 Jan 27;10(3):241–250. doi: 10.1002/cpdd.909

Table 2.

Nicotine Pharmacokinetic Parameters

A. C_max(0‐180) (ng/mL)
	Mean ± SD	Geo. LS Mean	Geo. LS Mean Ratio (95%CI), Test/Cigarette (%)	Geo. LS Mean Ratio (95%CI), Test/Gum (%)
Own‐brand cigarette (n = 26)	13.56 ± 7.1747	12.11
Nicotine polacrilex gum (n = 26)	2.781 ± 1.8058	2.04
Test 1 (n = 27)	2.894 ± 0.95257	2.73	22.57 (17.78‐28.65) ^a	133.72 (105.38‐169.69) ^b
Test 2 (n = 27)	3.133 ± 1.2021	2.90	23.99 (18.91‐30.45) ^a	142.14 (111.99‐180.40) ^b

B. AUC_0‐180 (ng·min/mL)
	Mean ± SD	Geo. LS Mean	Geo. LS Mean Ratio (95%CI), Test/Cigarette (%)	Geo. LS Mean Ratio (95%CI), Test/Gum (%)
Own‐brand cigarette (n = 26)	1017 ± 303.53	946.29
Nicotine polacrilex gum (n = 26)	332.0 ± 205.17	246.30
Test 1 (n = 27)	349.1 ± 121.81	327.11	34.57 (28.12‐42.49) ^a	132.81 (108.07‐163.21) ^b
Test 2 (n = 27)	380.0 ± 155.44	348.98	36.88 (30.01‐45.32) ^a	141.69 (115.28‐174.15) ^b

Values are presented as arithmetic mean ± SD, geometric least‐squares mean and geometric least‐squares mean ratio (%) with sample size (n) and the 95% confidence interval (CI) for the geometric mean ratio between the test products and own‐brand cigarette and nicotine polacrilex gum.

^{^a}

P < .0001.

^{^b}

P < .05.