Table 1.

Inhibitory activity of 8‐TQ, DPA, and conjugates 6–8 and 13–15 against selected MBLs.

	NDM‐1 IC50 [μm][a]	VIM‐2 IC50 [μm]	IMP‐1 IC50 [μm]	IMP‐28 IC50 [μm]
8‐TQ	2.99±0.58	4.20±1.00	4.42±0.14	4.20±0.11
6	2.31±0.25	3.64±0.27	12.21±0.25	10.32±0.22
7	2.18±0.14	6.35±0.56	33.57±1.72	71.87±3.05
8	8.47±1.02	4.17±0.65	28.92±1.29	46.24±3.13
DPA	3.13±0.12	4.34±0.67	15.16±0.17	9.65±0.62
13	2.13±0.07	1.87±0.10	5.22±0.25	7.39±0.10
14	0.299±0.005	0.756±0.056	15.09±1.09	46.70±2.76
15	18.78±1.22	10.83±0.60	18.71±2.43	61.87±1.82

[a] Half‐maximal inhibitory concentration of the compounds tested against NDM‐1, VIM‐2, IMP‐1, and IMP‐28. Inhibitors pre‐incubated with the MBL for 10 min followed by addition of the FC5 substrate (full assay details provided in the Supporting Information). Values reported based on triplicate experiments.