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. 2021 Mar 9;11:605606. doi: 10.3389/fonc.2021.605606

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Copyright © 2021 Bresesti, Vezzoli, Cangiano and Bonomi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of different lncRNA in testicular cancer pathogenesis. Testicular cancer cells proliferation is promoted by lncRNA HOTTIP and SPRY4-IT1, while it is inhibited by NCL1-C, which also drives testicular cancer cells apoptosis. Cisplatin-based treatments resistance can be promoted by the H19/TDRG1 pathway, since H19 is able to upregulate TDRG1, which in turn triggers therapy resistance. Finally, testicular tumor invasiveness is promoted by SPRY4-IT1, which not only increases the cell proliferative rate, but also their motility and invasiveness.