Table 2.
Summary of histopathological changes, brain regions, and studies
| Histopathological changes | Number of studies | Study IDs | Brain regions |
|---|---|---|---|
| 1. Accumulations of material | |||
| Intracytoplasmic eosinophilic inclusion bodies | 14 | 2; 3; 5; 7; 8; 11; 14; 19; 20; 21; 22; 25; 27; 36 |
Thalamus BG; BS: SN |
| Marinesco bodies | 6 | 7; 14; 22; 30; 33; 36 | SN |
| Neurofibrillary degeneration | 19 | 7; 8; 10; 12; 14; 20; 22; 25; 26; 27; 31; 33; 34; 35; 36; 37; 38; 39; 40 |
Limbic system: amygdala; HPC; CC; limbic Cortex; olfactory bulb CB; BG; NBM; BS: raphe; hypothalamus WM |
| Granulovacuolar degeneration | 4 | 7; 14; 38; 39 | HPC; CC: temporal |
| Plaques | 10 | 7; 8; 10; 14; 20; 22; 26; 35; 36; 40 | Whole brain with focus on limbic system and BS |
| RNA foci | 2 | 32; 41 |
CC; HPC; CB; thalamus; BS: SN WM: subcortical, callosal |
| Other accumulations | 6 | 14; 25; 28; 30; 35; 36 | CC: temporal; thalamus; CB; BG; BS: pons (locus coeruleus), medulla, SN |
| 2. Cellular alterations | |||
| Neuronal alterations | 21 | 1; 2; 4; 8; 9; 10; 12; 13; 15; 16; 17; 18; 22; 23; 24; 25; 27; 29; 30; 36; 40 |
Limbic system (CC: entorhinal; HPC) CC; BG; NBM; BS: SN, raphe nuclei, hypoglossal nucleus; medullary arcuate nucleus, MRF; CB WM |
| Glial alterations | 15 | 2; 4; 6; 8; 9; 16; 17; 22; 25; 30; 36; 40 |
Limbic system (CC: entorhinal cortex; HPC; olfactory bulb; amygdala) CC; thalamus; BG; NBM; CB; BS: raphe nuclei, medullary pyramids, SN, LC; hypothalamus WM |
| 3. White matter pathology | 14 | 4; 6; 9; 10; 11; 13; 22; 25; 27; 31; 32; 34; 36; 40 | WM: deep; subcortical; callosal |
The most/best studied brain regions are indicated in bold font.
BG, basal ganglia; BS, brain stem; CB, cerebellum; CC, cerebral cortex; HPC, hippocampus; LC, locus coeruleus; MRF, medullary reticular formation; NBM, nucleus basalis of Meynert; SN, substantia nigra; WM, white matter.