Figure 5.

Brain-behavioral model predicting symptom changes during transition to Huntington’s disease (HD). (A) Surface projection of weights that indicate whether a brain region contributes to the prediction of longitudinal motor scores over all time points (for model illustration and details, see Figure S5 and the bar plot of weights in Figure S5B, C). Results are from group-level model accounting for effects of age, gender, CAG, and confounds (see Methods and Materials). The right panel illustrates the observed Unified Huntington’s Disease Rating Scale Total Motor Score (TMS) (scaled to 0–100, gray) and individual model predictions (green) for 5 exemplary participants with varying CAG length, group-level model predictions (blue) using our HD progression model. See Figure S6 for all HD participant plots. x-axis: disease progression time in years relative to individual motor diagnosis. (B) Analogous findings for brain-based prediction of cognitive deficits. Symbol Digit Modalities Test (SDMT) score, inverted and scaled 0–100. (Bar plot of weights in Figure S5.)