Figure 2. Vaccination of Syrian hamsters with ChAdOx1 nCoV-19 prevents lower respiratory tract infection with SARS-CoV-2 VOC B.1.1.7.

a. Relative weight upon intranasal challenge with 10⁴ TCID₅₀ of B.1.1.7. Shown is geometric mean with 95% confidence interval (CI). * = p-value<0.05, corrected for multiple comparisons using the Holm-Šidák correction. b. Lung:body weight (BW) ratio (mg:g) of hamsters euthanized at 5 DPI. Line = median.c. sgRNA viral load in lung tissue obtained at 5 DPI. Line = median. Dotted line = limit of detection. d. Infectious SARS-CoV-2 titer in lung tissue obtained at 5 DPI. Line = median. Dotted line = limit of detection. e. Percentage affected lung tissue per animal as determined via histology. Line = median. f. Percentage of lung tissue positive for SARS-CoV-2 antigen per animal. Line = median. g. Truncated violin plot of area under the curve (AUC) analysis of shedding as measured by sgRNA analysis in swabs collected on 1 – 5 dpi. Dashed line = median. Dotted line = quartiles. Statistical significance determined via mixed-effect analyses (a), or Mann-Whitney test (b-g). V = ChAdOx1 nCoV-19 vaccinated; C = ChAdOx1 GFP vaccinated; Orange circle = Hamsters vaccinated with ChAdOx1 nCoV-19, Blue square = Hamsters vaccinated with ChAdOx1 GFP.