Figure 5. Pulmonary effects of direct intranasal challenge with SARS-CoV-2 variant B.1.351 in Syrian hamsters at 5 DPI.
a–b. H&E staining, 20x; a. No pathology. b. Focally extensive areas of bronchointerstitial pneumonia. c–d. H&E staining, 200x; c. No pathology. d. Bronchointerstitial pneumonia with alveolar histiocytosis, fibrin and edema. e–f. IHC staining against SARS-CoV-2 (brown). e. No staining. f. Staining of bronchiolar epithelial cells, type I&II pneumocytes and rare macrophages.