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[Preprint]. 2021 Mar 14:2021.03.13.435256. [Version 1] doi: 10.1101/2021.03.13.435256

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Fig. 1. — A. RNA scaffolds: (top) replication-transcription complex (RTC) scaffold (14); (bottom) backtrack complex scaffolds (BTC₃ and BTC₅).

B. A native gel electrophoretic mobility shift assay reveals that holo-RdRp requires nsp13(ADP-AlF₃) to bind the BTC scaffolds efficiently.

C. Cryo-EM structures of SARS-CoV-2 BTCs. Shown is the transparent cryo-EM density [local-resolution filtered; (47)] with the refined models superimposed (Table S1). The models and density are colored according to the key.