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[Preprint]. 2021 Mar 12:2021.03.08.21252784. [Version 1] doi: 10.1101/2021.03.08.21252784

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This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.

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Figure 4: — Functional activity of antibodies in COVID-19 naïve Malian samples (n=89) and positive control samples (n=11; recombinant nAb n=1, US convalescent serum n=10) A) Pseudovirus neutralization test of samples at lowest dilution (1:20) B) SARS-CoV-2 spike protein and RBD reactivity by ELISA in COVID-19 naïve Malian samples tested by pseudovirus neutralization test C) Pseudovirus neutralization test IC50 versus spike protein and RBD OD in positive control US clinical samples.

IC50: half maximal inhibitory concentration, LLOD: lower limit of detection, OD: optical density, RBD: receptor binding domain, recombinant nAb: recombinant neutralizing antibody H4 a-RBD hIgG1.