Table 3.
Association Between Change in Blood Parameters at Day 7 Post MPS Treatment and Clinical Endpoints
| Change in CRP from pre- treatment to post-treatment |
Total died, respiratory failure or MICU admission | |||
|---|---|---|---|---|
| Yes | No | Total | P | |
| Normal->normal or high->normal | 0 (0) | 45 (100%) | 45 | .00001 |
| High->High or Normal->high | 10 (35.7%) | 18 (64.3%) | 28 | |
| Change in LDH from pre- treatment to post-treatment |
Yes | No | Total | P |
| Normal->normal or high->normal | 2 (3.9%) | 49 (96%) | 51 | .0005 |
| High->High or Normal->high | 8 (38.1%) | 13 (61.9%) | 21 | |
| Change in Ferritin from pre-treatment to post- treatment |
Yes | No | Total | P |
| Normal->normal or high->normal | 1 (3.6%) | 27 (196.4%) | 28 | .14 |
| High->High or Normal->high | 7(16.3%) | 36 (83.7%) | 43 | |
| Change in D-dimers from pre-treatment to post- treatment |
Yes | No | Total | P |
| Normal->normal or high->normal | 0 (0) | 28 (100%) | 28 | .004 |
| High->High or Normal->high | 10(24.4%) | 31 (75.6%) | 41 | |
| Change in IL-6 from pre- treatment to post- treatment |
Yes | No | Total | P |
| Normal->normal or high->normal | 2 (3.8%) | 51 (96.2%) | 53 | .009 |
| High->High or Normal->high | 4 (33.3%) | 8 (66.7%) | 12 | |
| Change in ALC* from pre- treatment to post- treatment |
Yes | No | Total | P |
| Normal->normal or low->normal | 3 (4.7%) | 60 (95.2%) | 63 | <.00001 |
| Low->Low or Normal->Low | 8 (67%) | 4 (33.3%) | 12 | |
*
ALC= Absolute Lymphocyte Count