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. Author manuscript; available in PMC: 2021 Oct 23.
Published in final edited form as: Circ Res. 2020 Aug 28;127(10):1288–1305. doi: 10.1161/CIRCRESAHA.120.317439
Parameters Value Units Description
kA 0.3 ng · ml−1 · hr−1 BMP9 production rate
kB 0.2 ng · ml−1 · hr−1 BMP4 maximum production rate
kE 4 ng · ml−1 · hr−1 Endoglin maximum production rate
kS 1 ng · ml−1 · hr−1 ALK1 production rate
kM 2 ng−2 · ml2 · hr−1 MGP production rate
kC 2 ng−2 · ml2 · hr−1 CV2 production rate
θAC 0.5 ng−1 · ml · hr−1 Binding rate of BMP9 and CV2
θBM 0.1 ng−1 · ml · hr−1 Binding rate of BMP4 and MGP
μA 0.5 hr−1 Degradation rate of BMP9
μB 0.1 hr−1 Degradation rate of BMP4
μE 0.5 hr−1 Degradation rate of Engdolin
μS 1.5 hr−1 Degradation rate of ALK
μM 0.7 hr−1 Degradation rate of MGP
μC 0.7 hr−1 Degradation rate of CV2
p 0.1 ≈ 0.31 ng · ml−1
q 2 ≈ 1.4 ng · ml−1
τMGP 2 hr MGP transcriptional time delay
τCV2 8 hr CV2 transcriptional time delay
τALK1 1 hr ALK1 transcriptional time delay