Parameters | Value | Units | Description |
---|---|---|---|
kA | 0.3 | ng · ml−1 · hr−1 | BMP9 production rate |
kB | 0.2 | ng · ml−1 · hr−1 | BMP4 maximum production rate |
kE | 4 | ng · ml−1 · hr−1 | Endoglin maximum production rate |
kS | 1 | ng · ml−1 · hr−1 | ALK1 production rate |
kM | 2 | ng−2 · ml2 · hr−1 | MGP production rate |
kC | 2 | ng−2 · ml2 · hr−1 | CV2 production rate |
θAC | 0.5 | ng−1 · ml · hr−1 | Binding rate of BMP9 and CV2 |
θBM | 0.1 | ng−1 · ml · hr−1 | Binding rate of BMP4 and MGP |
μA | 0.5 | hr−1 | Degradation rate of BMP9 |
μB | 0.1 | hr−1 | Degradation rate of BMP4 |
μE | 0.5 | hr−1 | Degradation rate of Engdolin |
μS | 1.5 | hr−1 | Degradation rate of ALK |
μM | 0.7 | hr−1 | Degradation rate of MGP |
μC | 0.7 | hr−1 | Degradation rate of CV2 |
p | ≈ 0.31 | ng · ml−1 | |
q | ≈ 1.4 | ng · ml−1 | |
τMGP | 2 | hr | MGP transcriptional time delay |
τCV2 | 8 | hr | CV2 transcriptional time delay |
τALK1 | 1 | hr | ALK1 transcriptional time delay |