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. 2021 Mar 23;16(3):e0249003. doi: 10.1371/journal.pone.0249003

Table 3. Comparison of ETR and non-ETR group.

Variables, n (%) ETR (n = 22) Non-ETR (n = 21) P value
Gender (male) 15 (68.2) 15 (71.4) 0.817
Age > 70 year 12 (54.5) 12 (57.1) 0.864
Hepatitis B virus 11 (50.0) 12 (57.1) 0.639
Hepatitis C virus 10 (45.5) 5 (23.8) 0.137
Hypertension 8 (36.4) 13 (61.9) 0.094
Diabetes mellitus 7 (31.8) 5 (23.8) 0.558
Coronary artery disease 5 (22.7) 2 (9.5) 0.412
Liver cirrhosis 22 (100.0) 20 (95.2) 0.488
Child-Pugh Classification
 A 20 (90.9) 20 (95.2) > 0.999
 B 2 (9.1) 1 (4.8)
AJCC
 I-II 17 (77.3) 17 (81.0) > 0.999
 III 5 (22.7) 4 (19.0)
Number of tumors
 Single 19 (86.4) 14 (66.7) 0.162
 Multiple 3 (13.6) 7 (33.3)
Tumor size < 5 cm 20 (90.9) 11 (52.4) 0.005
Portal vein thrombosis 6 (27.3) 2 (9.5) 0.240
Hepatic vein thrombosis 3 (13.6) 0 (0) 0.233
Bile duct dilatation 2 (9.1) 4 (19.0) 0.412
Radiation dose
 72.6 GyE 11 (50.0) 14 (66.7) 0.268
 66 GyE 11 (50.0) 7 (33.3)
Complete response 20 (90.9) 5 (23.8) < 0.001
Local tumor control 21 (95.5) 19 (90.5) 0.607
Mortality 3 (13.6) 10 (47.6) 0.015

AJCC: American Joint Committee on Cancer 8th edition; CR: complete response; ETR: early tumor regression; GyE: Gray equivalents.