| A. Top Enriched IPA Pathways in Subset 1 |
B. Top Enriched IPA Pathways in Subset 2 |
| Ingenuity Canonical Pathways |
-log(p-value) |
Ingenuity Canonical Pathways |
-log(p-value) |
| Hepatic Fibrosis / Hepatic Stellate Cell Activation |
19.9 |
Granulocyte Adhesion and Diapedesis |
17.4 |
| Granulocyte Adhesion and Diapedesis |
15.4 |
Hepatic Fibrosis / Hepatic Stellate Cell Activation |
14.1 |
| Agranulocyte Adhesion and Diapedesis |
13.5 |
Agranulocyte Adhesion and Diapedesis |
13.7 |
| Osteoarthritis Pathway |
11.4 |
Atherosclerosis Signaling |
10.1 |
| Axonal Guidance Signaling |
8.83 |
Breast Cancer Regulation by Stathmin1 |
10.1 |
| Airway Pathology in Chronic Obstructive Pulmonary Disease |
8.16 |
Osteoarthritis Pathway |
9.64 |
| Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis |
8.03 |
Axonal Guidance Signaling |
9.52 |
| Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis |
7.65 |
LXR/RXR Activation |
8.78 |
| Breast Cancer Regulation by Stathmin1 |
7.37 |
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis |
7.56 |
| Inhibition of Matrix Metalloproteases |
7.14 |
cAMP-mediated signaling |
6.92 |
| C. Top Activated Reactome Pathways in Subset 1 |
D. Top Activated Reactome Pathways in Subset 2 |
| Pathway |
Description |
set Size |
enrichment Score |
NES |
p value |
adjusted p value |
q value |
Pathway |
Description |
set Size |
enrichment Score |
NES |
p value |
adjusted p value |
q value |
| R-HSA-1442490 |
Collagen degradation |
29 |
0.6439 |
2.88 |
0.0001 |
0.0019 |
0.0013 |
R-HSA-6805567 |
Keratinization |
42 |
0.6099 |
2.52 |
0.0001 |
0.0064 |
0.0050 |
| R-HSA-1474228 |
Degradation of the extracellular matrix |
47 |
0.5509 |
2.86 |
0.0001 |
0.0019 |
0.0013 |
R-HSA-6809371 |
Formation of the cornified envelope |
42 |
0.6099 |
2.52 |
0.0001 |
0.0064 |
0.0050 |
| R-HSA-1474290 |
Collagen formation |
28 |
0.6240 |
2.76 |
0.0001 |
0.0019 |
0.0013 |
R-HSA-1474228 |
Degradation of the extracellular matrix |
54 |
0.5163 |
2.26 |
0.0001 |
0.0064 |
0.0050 |
| R-HSA-2022090 |
Assembly of collagen fibrils and other multimeric structures |
22 |
0.6699 |
2.75 |
0.0002 |
0.0019 |
0.0013 |
R-HSA-1442490 |
Collagen degradation |
34 |
0.5622 |
2.21 |
0.0001 |
0.0064 |
0.0050 |
| R-HSA-1474244 |
Extracellular matrix organization |
78 |
0.4502 |
2.64 |
0.0001 |
0.0019 |
0.0013 |
R-HSA-1592389 |
Activation of Matrix Metalloproteinases |
19 |
0.6468 |
2.19 |
0.0001 |
0.0064 |
0.0050 |
| R-HSA-1650814 |
Collagen biosynthesis and modifying enzymes |
23 |
0.6172 |
2.57 |
0.0002 |
0.0019 |
0.0013 |
R-HSA-5617833 |
Cilium Assembly |
50 |
0.4519 |
1.95 |
0.0014 |
0.0360 |
0.0284 |
| R-HSA-8948216 |
Collagen chain trimerization |
18 |
0.6468 |
2.47 |
0.0003 |
0.0030 |
0.0021 |
R-HSA-1474290 |
Collagen formation |
37 |
0.4759 |
1.91 |
0.0026 |
0.0432 |
0.0341 |
| R-HSA-6805567 |
Keratinization |
19 |
0.6327 |
2.47 |
0.0002 |
0.0019 |
0.0013 |
R-HSA-1852241 |
Organelle biogenesis and maintenance |
53 |
0.4238 |
1.85 |
0.0028 |
0.0432 |
0.0341 |
| R-HSA-6809371 |
Formation of the cornified envelope |
19 |
0.6327 |
2.47 |
0.0002 |
0.0019 |
0.0013 |
R-HSA-2022090 |
Assembly of collagen fibrils and other multimeric structures |
28 |
0.4891 |
1.84 |
0.0049 |
0.0515 |
0.0406 |
| R-HSA-1640170 |
Cell Cycle |
51 |
0.4204 |
2.23 |
0.0003 |
0.0029 |
0.0020 |
R-HSA-69620 |
Cell Cycle Checkpoints |
46 |
0.4288 |
1.81 |
0.0055 |
0.0515 |
0.0406 |
