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. 2021 Mar 23;16(3):e0248851. doi: 10.1371/journal.pone.0248851

Table 1. Group mean (± one standard deviation, SD) results for the considered parameters and the results of ANOVA test (P value).

Variables HC (n = 69) NGS (n = 72) POAG (n = 70) P value (ANOVA)
Mean age (years) 65.0 ± 9.0 67.6 ± 8.0 68.0 ± 8.0 0.078
Males (n)/Females (n) 23/46 19/53 28/42 -
Mean CCT (μm) 562 ± 39 547 ± 31 542 ± 33 0.002
Mean IOP (mmHg) 17.0 ± 3.0 17.0 ± 3.0 16.0 ± 3.0 0.446
Mean VF MD (dB) −0.37 ± 1.04 −0.28 ± 1.12 −8.64 ± 7.71 <0.001
Mean VF PSD (dB) 1.64 ± 0.42 1.60 ± 0.32 6.61 ± 3.95 <0.001
Disc area (HRT parameter) (mm2) 2.26 ± 0.40 2.31 ± 0.34 2.12 ± 0.32 0.005
Rim area (HRT parameter) (mm2) 1.61 ± 0.31 1.16 ± 0.21 0.87 ± 0.31 <0.001§
Rim volume (HRT parameter) (mm3) 0.43 ± 0.11 0.25 ± 0.09 0.16 ± 0.10 <0.001§
Average RNFL thickness (μm) 96.5 ± 8.3 86.4 ± 10.1 64.0 ± 12.6 <0.001§
Temporal Superior RNFL (μm) 135.2 ± 14.6 119.6 ± 20.5 80.6 ± 24.1 <0.001§
Temporal RNFL (μm) 70.2 ± 10.4 64.5 ± 10.8 50.6 ± 13.4 <0.001§
Temporal Inferior RNFL (μm) 141.8 ± 17.7 123.1 ± 22.7 75.3 ± 29.5 <0.001§
Nasal Superior RNFL (μm) 104.2 ± 20.5 90.2 ± 17.5 70.7 ± 18.0 <0.001§
Nasal RNFL (μm) 72.1 ± 11.6 66.0 ± 12.1 56.1 ± 16.1 <0.001§
Nasal Inferior RNFL (μm) 108.2 ± 19.7 98.0 ± 18.9 72.2 ± 22.4 <0.001§
LCD (μm) 532 ± 116 563 ± 117 600 ± 173 0.015
LCDD 224 ± 59 216 ± 56 241 ± 68 0.048¶¶
LCSI 0.36 ± 0.13 0.33 ± 0.17 0.35 ± 0.15 0.357
LCSI_H −0.19 ± 0.36 −0.02 ± 0.42 −0.02 ± 0.41 0.015
Systolic BP (mmHg) 143 ± 17 145 ± 17 145 ± 20 0.744
Diastolic BP (mmHg) 86 ± 10 86 ± 10 89 ± 12 0.113
MAP (mmHg) 105 ± 11 106 ± 11 108 ± 14 0.383
MOPP (mmHg) 59 ± 8 59 ± 7 61 ± 9 0.229
Hypertension (n) 21 18 14 -

HC = healthy controls; NGS = normotensive glaucoma suspects; POAG = primary open-angle glaucoma; CCT = central corneal thickness; IOP = intraocular pressure; VF MD = visual field mean deviation; VF PSD = visual field pattern standard deviation; HRT = Heidelberg Retina Tomography; RNFL = retinal nerve fiber layer; LCD = lamina cribrosa depth; LCDD = lamina cribrosa deflection depth; LCSI = lamina cribrosa shape index; LCSI_ H = lamina cribrosa shape index in a horizontal direction; BP = blood pressure; MAP = mean arterial pressure; MOPP = mean ocular perfusion pressure; values with statistical significance are shown in bold

† P value is significant between normal and suspects and between normal and POAG.

‡ P value is significant between normal and POAG and between suspects and POAG.

§ P value is significant among all groups.

¶ P value is significant between normal and POAG.

¶¶ P value is significant between suspects and POAG.

All P values including with Bonferroni correction (α<0.05/3).