Table 1. Group mean (± one standard deviation, SD) results for the considered parameters and the results of ANOVA test (P value).
| Variables | HC (n = 69) | NGS (n = 72) | POAG (n = 70) | P value (ANOVA) |
|---|---|---|---|---|
| Mean age (years) | 65.0 ± 9.0 | 67.6 ± 8.0 | 68.0 ± 8.0 | 0.078 |
| Males (n)/Females (n) | 23/46 | 19/53 | 28/42 | - |
| Mean CCT (μm) | 562 ± 39 | 547 ± 31 | 542 ± 33 | 0.002† |
| Mean IOP (mmHg) | 17.0 ± 3.0 | 17.0 ± 3.0 | 16.0 ± 3.0 | 0.446 |
| Mean VF MD (dB) | −0.37 ± 1.04 | −0.28 ± 1.12 | −8.64 ± 7.71 | <0.001‡ |
| Mean VF PSD (dB) | 1.64 ± 0.42 | 1.60 ± 0.32 | 6.61 ± 3.95 | <0.001‡ |
| Disc area (HRT parameter) (mm2) | 2.26 ± 0.40 | 2.31 ± 0.34 | 2.12 ± 0.32 | 0.005‡ |
| Rim area (HRT parameter) (mm2) | 1.61 ± 0.31 | 1.16 ± 0.21 | 0.87 ± 0.31 | <0.001§ |
| Rim volume (HRT parameter) (mm3) | 0.43 ± 0.11 | 0.25 ± 0.09 | 0.16 ± 0.10 | <0.001§ |
| Average RNFL thickness (μm) | 96.5 ± 8.3 | 86.4 ± 10.1 | 64.0 ± 12.6 | <0.001§ |
| Temporal Superior RNFL (μm) | 135.2 ± 14.6 | 119.6 ± 20.5 | 80.6 ± 24.1 | <0.001§ |
| Temporal RNFL (μm) | 70.2 ± 10.4 | 64.5 ± 10.8 | 50.6 ± 13.4 | <0.001§ |
| Temporal Inferior RNFL (μm) | 141.8 ± 17.7 | 123.1 ± 22.7 | 75.3 ± 29.5 | <0.001§ |
| Nasal Superior RNFL (μm) | 104.2 ± 20.5 | 90.2 ± 17.5 | 70.7 ± 18.0 | <0.001§ |
| Nasal RNFL (μm) | 72.1 ± 11.6 | 66.0 ± 12.1 | 56.1 ± 16.1 | <0.001§ |
| Nasal Inferior RNFL (μm) | 108.2 ± 19.7 | 98.0 ± 18.9 | 72.2 ± 22.4 | <0.001§ |
| LCD (μm) | 532 ± 116 | 563 ± 117 | 600 ± 173 | 0.015¶ |
| LCDD | 224 ± 59 | 216 ± 56 | 241 ± 68 | 0.048¶¶ |
| LCSI | 0.36 ± 0.13 | 0.33 ± 0.17 | 0.35 ± 0.15 | 0.357 |
| LCSI_H | −0.19 ± 0.36 | −0.02 ± 0.42 | −0.02 ± 0.41 | 0.015† |
| Systolic BP (mmHg) | 143 ± 17 | 145 ± 17 | 145 ± 20 | 0.744 |
| Diastolic BP (mmHg) | 86 ± 10 | 86 ± 10 | 89 ± 12 | 0.113 |
| MAP (mmHg) | 105 ± 11 | 106 ± 11 | 108 ± 14 | 0.383 |
| MOPP (mmHg) | 59 ± 8 | 59 ± 7 | 61 ± 9 | 0.229 |
| Hypertension (n) | 21 | 18 | 14 | - |
HC = healthy controls; NGS = normotensive glaucoma suspects; POAG = primary open-angle glaucoma; CCT = central corneal thickness; IOP = intraocular pressure; VF MD = visual field mean deviation; VF PSD = visual field pattern standard deviation; HRT = Heidelberg Retina Tomography; RNFL = retinal nerve fiber layer; LCD = lamina cribrosa depth; LCDD = lamina cribrosa deflection depth; LCSI = lamina cribrosa shape index; LCSI_ H = lamina cribrosa shape index in a horizontal direction; BP = blood pressure; MAP = mean arterial pressure; MOPP = mean ocular perfusion pressure; values with statistical significance are shown in bold
† P value is significant between normal and suspects and between normal and POAG.
‡ P value is significant between normal and POAG and between suspects and POAG.
§ P value is significant among all groups.
¶ P value is significant between normal and POAG.
¶¶ P value is significant between suspects and POAG.
All P values including with Bonferroni correction (α<0.05/3).