Table 2. Ocular blood flow biomarkers in orbital vessels obtained using color Doppler Imaging device (mean ± one standard deviation, SD) and the results of ANOVA test (P value).
| Variables | HC (n = 69) | NGS (n = 72) | POAG (n = 70) | P value (ANOVA) |
|---|---|---|---|---|
| OA, PSV, cm/s | 35.59 ± 8.9 | 34.18 ± 8.9 | 30.66 ± 8.9 | 0.004† |
| OA, EDV, cm/s | 8.26 ± 3.2 | 8.30 ± 3.5 | 7.48 ± 2.9 | 0.233 |
| OA, Vm, cm/s | 17.81 ± 5.5 | 16.95 ± 5.5 | 15.38 ± 4.9 | 0.026† |
| OA, PI | 1.57 ± 0.3 | 1.57 ± 0.3 | 1.55 ± 0.4 | 0.889 |
| OA, RI | 0.77 ± 0.1 | 0.76 ± 0.1 | 0.75 ± 0.1 | 0.401 |
| CRA, PSV, cm/s | 14.28 ± 2.8 | 13.85 ± 3.2 | 12.55 ± 2.9 | 0.002‡ |
| CRA, EDV, cm/s | 4.04 ± 1.0 | 4.16 ± 0.9 | 3.92 ± 1.2 | 0.404 |
| CRA, Vm, cm/s | 7.84 ± 1.5 | 7.74 ± 1.6 | 7.12 ± 1.6 | 0.017‡ |
| CRA, PI | 1.30 ± 0.3 | 1.26 ± 0.3 | 1.22 ± 0.3 | 0.175 |
| CRA, RI | 0.71 ± 0.1 | 0.69 ± 0.1 | 0.68 ± 0.1 | 0.112 |
| NPCA, PSV, cm/s | 12.99 ± 2.6 | 13.74 ± 3.1 | 13.19 ± 3.6 | 0.339 |
| NPCA, EDV, cm/s | 4.09 ± 1.4 | 4.47 ± 1.4 | 4.20 ± 1.1 | 0.215 |
| NPCA, Vm, cm/s | 7.80 ± 1.5 | 8.20 ± 1.7 | 7.73 ± 1.8 | 0.204 |
| NPCA, PI | 1.16 ± 0.3 | 1.14 ± 0.2 | 1.15 ± 0.2 | 0.938 |
| NPCA, RI | 0.68 ± 0.1 | 0.67 ± 0.1 | 0.67 ± 0.1 | 0.860 |
| TPCA, PSV, cm/s | 14.30 ± 2.6 | 13.20 ± 2.9 | 13.14 ± 3.2 | 0.050 |
| TPCA, EDV, cm/s | 4.31 ± 1.4 | 4.07 ± 1.2 | 4.23 ± 1.4 | 0.558 |
| TPCA, Vm, cm/s | 8.34 ± 1.7 | 7.77 ± 1.5 | 7.81 ± 1.6 | 0.063 |
| TPCA, PI | 1.20 ± 0.3 | 1.18 ± 0.3 | 1.14 ± 0.3 | 0.511 |
| TPCA, RI | 0.69 ± 0.1 | 0.68 ± 0.1 | 0.67 ± 0.1 | 0.551 |
HC = healthy controls; NGS = normotensive glaucoma suspects; POAG = primary open-angle glaucoma; OA = ophthalmic artery; CRA = central retinal artery; NPCA = nasal short posterior ciliary artery; TPCA = temporal short posterior ciliary artery; PSV = peak systolic velocity; EDV = end diastolic velocity; Vm = mean flow velocity; PI = pulsatility index; RI = resistance index; values with statistical significance are shown in bold
† P value is significant between normal and POAG.
‡P value is significant between normal and POAG and between suspects and POAG.
All P values including with Bonferroni correction (α<0.05/3).