Table 3. Unadjusted and adjusted associations of host response biomarkers with average glucose over the first two days of ICU admission.
| Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
| Variable | B-Coefficient | Standard Error | p-value | B-Coefficient | Standard Error | p-value |
| IL-8 | -0.011 | 0.020 | 0.756 | |||
| IL-6 | -0.015 | 0.014 | 0.437 | |||
| TNFr1 | 0.013 | 0.038 | 0.809 | |||
| IL-1ra | 0.039 | 0.031 | 0.372 | |||
| ST2 | 0.055 | 0.020 | 0.035 | 0.031 | 0.015 | 0.047 |
| Fractalkine | 0.001 | 0.017 | 0.975 | |||
| RAGE | 0.044 | 0.036 | 0.372 | |||
| Ang2 | 0.048 | 0.027 | 0.235 | |||
| Procalcitonin | 0.051 | 0.019 | 0.035 | 0.035 | 0.014 | 0.028 |
| Pentraxin-3 | 0.031 | 0.018 | 0.235 | |||
Biomarker levels and average glucose were log transformed prior to analysis. Reported p-values have been adjusted for multiple comparisons. Multivariate analyses were adjusted for age, history of diabetes, total insulin dose, total glucocorticoid dose, and SOFA score. Abbreviations: ICU- intensive care unit; Ang2- angiopoietin 2; IL-6- interleukin-6; IL-8- interleukin-8; RAGE- receptor for advanced glycation end-products; ST2- suppressor of tumorigenicity 2; TNFr1- tumor-necrosis factor receptor 1.