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. Author manuscript; available in PMC: 2021 Mar 23.
Published in final edited form as: Leukemia. 2020 Feb 24;34(9):2375–2383. doi: 10.1038/s41375-020-0775-3

Fig. 4. Characterization of MSC-reprogrammed BM resident macrophages isolated from leukemia-bearing mice.

Fig. 4

a Gene set enrichment analysis (GSEA) of the positive regulation of angiogenesis and cell migration-related genes in L-Mac and E-Mac. L-Mac indicates leukemic macrophages. E-Mac indicates MSC-reprogrammed leukemic macrophages, which were co-cultured with MSCs in vitro for 12 h. b RNA-Seq analysis of Arg1 in L-Mac and E-Mac in vitro. c RNA-Seq analysis of Arg1 in leukemic macrophages sorted from MSC-treated leukemic mice in vivo. d Representative intracellular staining plots of Arg1 proteins in L-Mac and E-Mac. e Statistical analysis of the ratios of Arg1high macrophage subpopulation in L-Mac and E-Mac (mean ± SD, n = 4). Asterisks indicate **p < 0.01, ***p < 0.001 (unpaired student’s t-test (two-tailed)).