Table 2.
Natural Products Used in Reducing Cisplatin Toxicity and Suppressing Its Resistance
| Natural Compound | Organism | Category | Signaling Pathway | Year | Reference |
|---|---|---|---|---|---|
| Melatonin | Homo sapiens | Hormone | Nrf2 | 2020 | [161] |
| Resveratrol | Several plants | Polyphenol | Nrf2 | 2020 | [162] |
| Berberine | Berberis aristata | Isoquinoline Alkaloid | Nrf2 | 2019 | [163] |
| Luteolin | Reseda luteola | Flavonoid | Sox2 | 2016 | [252] |
| Cryptotanshinone | Salvia miltiorrhiza Bunge | Quinoid | Nrf2 | 2015 | [253] |
| Licorice | Glycyrrhiza glabra | Hydroalcohol | CYP1B1 | 2017 | [254] |
| Novobiocin | Streptomyces niveus | Antibiotic | HSP90 | 2008 | [255] |
| Tangeretin | Citrus Fruits | Flavonoid | PI3K/Akt | 2009 | [256] |
| Shikonin | Lithospermum erythrorhizon | Napthoquinones | Pyruvate Kinase M2 | 2017 | [257] |
| Diallyl trisulfide | Allium sativum | Organosulfide | Nrf2 | 2017 | [258] |
| Curcumin | Curcumin longa | Polyphenol | BRCA | 2014 | [259] |
| Vitamin C | N/A | Ascorbic Acid | P53 | 2016 | [260] |
| Celastrol | Tripterygium wilfordii | Triterpenoid | ERK1/2 and p38 MAPK | 2019 | [261] |
| Chinese Bayberry Leaves | Myrica rubra | Proanthocyanidins | HIF-1α and VEGF | 2018 | [262] |
| Oleuropein | Olea europaea | Monoterpenoids | Matrix metalloproteinase | 2018 | [263] |
| Terrein | Aspergillus terreus | Cyclopentanone | ERK | 2017 | [264] |