Table 2.
Univariable and Multivariable Analyses for Identifying Risk Factors Associated with PFS
| Characteristics | Univariable Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age ≥60 vs <60 years | 1.311 (0.999–1.720) | 0.051 | 1.247 (0.947–1.642) | 0.115 |
| Gender Male vs female | 1.065 (0.812–1.398) | 0.647 | ||
| Smoking status smoker vs nonsmoker | 0.986 (0.691–1.408) | 0.986 | ||
| ECOG 0 vs 1–2 | 0.957 (0.732–1.251) | 0.745 | ||
| EGFR mutation exon 19 vs others | 0.694 (0.530–0.909) | 0.008 | 0.707 (0.539–0.927) | 0.012 |
| Liver metastasis with vs without | 1.476 (0.920–2.370) | 0.107 | ||
| Adrenal metastasis with vs without | 0.852 (0.451–1.608) | 0.621 | ||
| Leptomeningeal metastases with vs without | 1.060 (0.393–2.857) | 0.908 | ||
| Brain parenchyma metastasis with vs without | 1.139 (0.844–1.539) | 0.395 | ||
| Pericardial metastasis with vs without | 1.308 (0.579–2.951) | 0.518 | ||
| Extrathoracic lymph node metastasis with vs without | 1.388 (1.014–1.899) | 0.040 | 1.322 (0.963–1.815) | 0.084 |
| Lung metastasis (contralateral) with vs without | 0.871 (0.664–1.144) | 0.871 | ||
| Pleural metastasis with vs without | 0.945 (0.711–1.256) | 0.698 | ||
| Bone metastasis with vs without | 1.081 (0.826–1.416) | 0.569 | ||
| Metastasis to other organs with vs without | 0.982 (0.462–2.091) | 0.963 | ||
| Number of organs with metastasis multi-organ vs single-organ | 0.962 (0.734–1.262) | 0.781 | ||
Abbreviations: PFS, progression-free survival; HR, hazard ratio; CI, confidence interval.