Author response image 4. Cluster size determination with different methods.

A, Silhouette method. For our data, measured silhouettes do not form global or local maxima at certain cluster numbers, but form plateaus around certain values. Usually our determined value (orange line) fell within this plateau. B, Elbow method. Usually our method delivered values that were close to what came closest to an elbow. C, Gap method. Steps in gap value at certain cluster sizes were usually at our or close to our determined value.