Table 2. The potency of clemizole (CMZ) on various human TRPC5 (hTRPC5) constructs.

TRPC5 constructs	CMZ
	LogIC50*	Hill slope	IC50 (μM)
hTRPC5 WT	0.49 ± 0.08	−2.52	3.07
Mutations in CMZ-binding pocket
F414M	0.33 ± 0.06	−1.45	2.15
N443L	1.02 ± 0.15	−2.42	10.43
S495A	0.48 ± 0.15	−1.21	3.03

^* Data were expressed as logIC₅₀ ± SEM, n = 3.