Table 2.

Main Contraindications of Both Hydroxychloroquine and Azithromycin

	Hydroxychloroquine	Azithromycine
Absolute contraindications	Hypersensitivity to active substances (cross-reactivity): hydroxychloroquine or chloroquine, amino-4 quinoleines, amodiaquine, mefloquine, glafenine, floctafenine, antrafenine. Increased risk of cardiac arrhythmia: citalopram, escitalopram, hydroxyzine, domperidone, and piperaquine. Pathophysiology: retinopathy, age <6 years, weight <35 kg.	Hypersensitivity to active substances (cross-reactivity): azithromycin, erythromycin, chlarithromycin, dirithromycin, josamycin, midecamycin diacetate, roxithromycin, telithromycin, macrolides, ketolides, everolimus, pimecrolimus, sirolimus, temsirolimus, fidaxomicine. Hypersensitivity to excipient: peanut oil and soy. Hypersensitivity to lactose, abnormality of galactose metabolism, lactase deficiency, and digestive malabsorption/intolerance syndrome because of the presence of lactose as excipient. Pathophysiology: pseudomembranous colitis, anaphylactic shock, severe skin involvement, acute exanthematic pustulosis, DRESS syndrome, severe liver failure, patient taking colchicine, cisapride, dihydroergotamine, and ergotamine.
Relative contraindication or not recommended	Hepatic porphyria, lactation, G6PD deficiency, psoriasis, hypersensitivity to lactose, abnormality of galactose metabolism, lactase deficiency, and digestive malabsorption/intolerance syndrome because of the presence of lactose as excipient.	Cholestase, colchicine, cisapride, dihydroergotamine, and ergotamine.

DRESS, drug reaction with eosinophilia and systemic symptoms.