Fig. 2.

( A ) A 17-year-old man with a left orbital macrocystic lymphaticovenous malformation. Axial ( B ), coronal ( C ) and sagittal ( D ) T1-weighted FS postcontrast magnetic resonance imaging (MRI) depicts a macrocystic multilobuled intraconal lesion surrounding the optic nerve. ( E ) Histopathology of a different patient affected by a microcystic lymphatic malformation demonstrating serous and venous spaces with vascularized stromal follicles and inflammatory fibrosis (hematoxylin and eosin [H&E] staining ×4). ( F ) Extensive vascular endothelial growth factor (VEGF) stromal staining and of a budding element (arrow; VEGF staining × 4). ( G ) Neovascularization in lumen and stroma. ( H ) Direct puncture contrast injection of a different patient's macrocystic malformation demonstrates a component with distinct internal lymphatic network.