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. 2021 Mar 15;2021:6636856. doi: 10.1155/2021/6636856

Table 2.

The statistical methods of all involved studies in this meta-analysis.

Year First author Country Sample size Study type Statistical method Adjustment for confounders Effect estimate
2002 Kleijn Netherlands 9450 Cohort study Cox proportional hazards model Age, hormone replacement therapy use, hypertension, BMI, and social economic class. HR
2006 Amagai Japan 4683 Cohort study Cox proportional hazard model Age, SBP, TC, HDL-C, history of DB, BMI, smoking, alcohol, marital status, study area, and type of menopause. HR
2006 Cui Japan 37965 Cohort study Cox proportional hazard model Age, smoking, alcohol, marital status, type of menopause, education, hypertension, and diabetes. HR
2007 Hong Korea 2658 Cohort study Cox proportional hazards model Age, alcohol consumption, education, age at first birth, self-cognitive health level, chronic disease, marital partner, parity, age at menarche, oral contraceptive use, and hypertension. HR
2012 Tom USA 1684 Cohort study Cox proportional hazards model Age, education, pregnancy number, age at menarche, smoking, height, weight, and use of ET. HR
2014 Wu China 31955 Cohort study Cox proportional hazard model Age at study enrollment, BMI, WHR, education, occupation, income, regular exercise, current smoking or alcohol, marital status, age at menarche, and number of live births. HR
2018 Lay Brazil 868 Cohort study Cox regression model Social, year of birth, education, marital status, race, reproductive, parity, smoking, number of chronic diseases, and ET. HR
2019 Malek USA 11287 Cohort study Cox proportional hazards model Age, race, education, medical conditions, behavioral characteristics, and type of menopause. HR
2019 Zhang USA 75359 Cohort study Cox proportional hazards model Baseline age, race, BMI, smoking, alcohol, marital status, education level, physical exercise, hormone replacement therapy use, CVD history, number of live births, age at first birth, and type of menopause. HR
2020 Shen Taiwan 36931 Cohort study Cox proportional hazards model Birth cohort, education, smoking status, body mass index, hypertension, diabetes, and high blood cholesterol. HR
1998 Cooper USA 3191 Cohort study Poisson regression procedures Age, education, race, smoking, use of estrogen therapy, and years of follow-up. RR
1999 Jacobsen USA 5279 Cohort study Proportional hazards model DB, hypertension, parity, age at first birth, leisure PA, education, BMI, current use of estrogen, ever-smoking, vegetarian status, and dietary pattern. RR
2000 Cooper USA 826 Cohort study Logistic regression model Age, smoking, use of estrogen replacement therapy, and parity. RR
2003 Jacobsen Norway 19731 Cohort study Cox proportional hazards model Attained age, county, occupation, and birth cohort. RR
2005 Mondul USA 68154 Cohort study Cox proportional hazards model Age, race, marital status, BMI, age at menarche, parity, education, alcohol, oral contraceptive use, and exercise. RR
2013 Li USA 11212 Cohort study Cox proportional hazard model Age and time period, education, marital status, BMI, smoking, alcohol, PE, dietary pattern, menarche age, parity or first birth, reproductive factors, contraceptive use, lactation duration, and unilateral oophorectomy. RR

RR: relative risk; HR: hazard ratio; BMI: body mass index; SBP: systolic blood pressure; CVD: cardiovascular disease; HDL-C: high-density lipoprotein cholesterol; PE: physical education; TC: total cholesterol; DB: diabetes mellitus; WHR: waist-to hip ratio; PA: physical activity.