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. 2021 Mar 16;2021:5534614. doi: 10.1155/2021/5534614

Figure 4.

Figure 4

Agnuside inhibits HIF-1α accumulation and NLRP3 inflammasome activation in LPS-treated FLSs. (a) Relative caspase-1 activity for each group. ∗P < 0.05, in comparison with the normal group. #P < 0.05, in comparison with the LPS group. (b) mRNA level of HIF-1α, caspase-1, ASC, and NLRP3 in each group. ∗P < 0.05, ∗∗P < 0.01, in comparison with the normal group. #P < 0.05, ##P < 0.01, in comparison with the KOA group. (c) Typical protein bands for each group. (d) Protein level comparison of HIF-1α, pro-caspase-1, caspase-1 p10, ASC, and NLRP3 between groups. ∗∗P < 0.01, compared with the normal group. ##P < 0.01, compared with the KOA group. (e) FLS supernatant contents of IL-1β and IL-18 between groups. ∗∗P < 0.01, compared with the normal group. ##P < 0.01, compared with the KOA group.