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. 2021 Mar 22;6(3):222–235. doi: 10.1016/j.jacbts.2020.12.014

Figure 4.

Figure 4

Endothelial Cell Tubule Formation is Abnormal in Patients With a Glenn Circulation

(A,B) In a Matrigel assay, endothelial cell hub and tubule counts were significantly lower with Glenn IVC and PA plasma than with control plasma. Glenn PA plasma significantly increased endothelial cell hub and tubule counts versus Glenn IVC plasma. (C to E) Characteristic micrographics of endothelial cells grown with control plasma and Glenn IVC and PA plasma are shown. Large endothelial hubs composed of many adherent cells and lower tubule counts were noted with plasma from Glenn IVC and PA plasma but not control plasma. Abbreviations as in Figure 1.